About: A Transgenic Approach to Identify Thyroxine Transporter-Expressing Structures in Brain Development

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About: A Transgenic Approach to Identify Thyroxine Transporter-Expressing Structures in Brain Development Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1111/j.1365-2826.2011.02216.x
Description	Transporters are essential in thyroid hormone metabolism. Thyroxine (T4) is transported by solute carrier organic anion transporter 1c1 (SLCO1C1, OATP14) into the adult brain, where T4 is converted to 3,5,3 - triiodothyronine (T3). In adults, SLCO1C1 expression is found in two brain barrier structures: the blood–brain barrier (BBB) and choroid plexus. However, a little is known about the T4 transport in the developing brain, when the BBB is not yet completely formed. We investigated the expression of SLCO1C1 in double transgenic mice, which were generated by recombination of bacterial Cre recombinase into the Slco1c1 locus (Slco1c1-Cre mice). It was demonstrated that SLCO1C1 is expressed in the neuronal cell lineage during brain development. Results suggested that expression of SLCO1C1 may underlie the extraordinary sensitivity of specific neuronal populations to hypothyroxinaemia. Transporters are essential in thyroid hormone metabolism. Thyroxine (T4) is transported by solute carrier organic anion transporter 1c1 (SLCO1C1, OATP14) into the adult brain, where T4 is converted to 3,5,3 - triiodothyronine (T3). In adults, SLCO1C1 expression is found in two brain barrier structures: the blood–brain barrier (BBB) and choroid plexus. However, a little is known about the T4 transport in the developing brain, when the BBB is not yet completely formed. We investigated the expression of SLCO1C1 in double transgenic mice, which were generated by recombination of bacterial Cre recombinase into the Slco1c1 locus (Slco1c1-Cre mice). It was demonstrated that SLCO1C1 is expressed in the neuronal cell lineage during brain development. Results suggested that expression of SLCO1C1 may underlie the extraordinary sensitivity of specific neuronal populations to hypothyroxinaemia. (en)
Title	A Transgenic Approach to Identify Thyroxine Transporter-Expressing Structures in Brain Development A Transgenic Approach to Identify Thyroxine Transporter-Expressing Structures in Brain Development (en)
skos:prefLabel	A Transgenic Approach to Identify Thyroxine Transporter-Expressing Structures in Brain Development A Transgenic Approach to Identify Thyroxine Transporter-Expressing Structures in Brain Development (en)
skos:notation	RIV/00216208:11110/11:9289!RIV12-MSM-11110___
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hroudová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	184232
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/11:9289
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	solute carrier organic anion transporter 1c1; thyroxine transporter; thyroid hormones; hypothyroidism; brain development (en)
http://linked.open.../riv/klicoveSlovo	thyroid hormones brain development hypothyroidism solute carrier organic anion transporter 1c1 thyroxine transporter
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[344BCDC21E51]
http://linked.open...i/riv/nazevZdroje	Journal of Neuroendocrinology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Berger, S. Hroudová, Jana Kleesiek, Jens Lang, M. F. Ridder, Dirk A. Salinin, S. Schwaninger, M. Schütz, G.
http://linked.open...ain/vavai/riv/wos	000297844400002
issn	0953-8194
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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