About: Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3)     Goto   Sponge   NotDistinct   Permalink

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Description
  • Sequencing of the PRMT3 gene in patients from the Czech DBA registry revealed a heterozygous mutation encoding the Tyr87Cys substitution. To address the impact of the mutation and putative Tyr87 phosphorylation on PRMT3 properties, we constructed two additional PRMT3 variants, Tyr87Phe and Tyr87Glu PRMT3, mimicking non-phosphorylated and phosphorylated Tyr87, respectively and studied their activity. In conclusion, Tyr87 is important for the interaction between PRMT3 and RPS2 and for its full enzymatic activity
  • Sequencing of the PRMT3 gene in patients from the Czech DBA registry revealed a heterozygous mutation encoding the Tyr87Cys substitution. To address the impact of the mutation and putative Tyr87 phosphorylation on PRMT3 properties, we constructed two additional PRMT3 variants, Tyr87Phe and Tyr87Glu PRMT3, mimicking non-phosphorylated and phosphorylated Tyr87, respectively and studied their activity. In conclusion, Tyr87 is important for the interaction between PRMT3 and RPS2 and for its full enzymatic activity (en)
Title
  • Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3)
  • Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3) (en)
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  • Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3)
  • Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3) (en)
skos:notation
  • RIV/00216208:11110/11:8913!RIV12-MZ0-11110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(GA305/09/1390), P(LC06044), P(LC07017), P(NS10300), Z(AV0Z50200510), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 236425
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/11:8913
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • PRMT3; RPS2; arginine methylation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [389386A2A51A]
http://linked.open...i/riv/nazevZdroje
  • Biochimica et Biophysica Acta - Proteins and Proteomics
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 1814
http://linked.open...iv/tvurceVysledku
  • Halada, Petr
  • Petrák, Jiří
  • Pospíšilová, Dagmar
  • Handrková, Helena
  • Čmejla, Radek
http://linked.open...ain/vavai/riv/wos
  • 000287067700002
http://linked.open...n/vavai/riv/zamer
issn
  • 1570-9639
number of pages
http://localhost/t...ganizacniJednotka
  • 11110
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