About: Humoral immune response to keyhole limpet haemocyanin, the protein carrier in cancer vaccines

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About: Humoral immune response to keyhole limpet haemocyanin, the protein carrier in cancer vaccines Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1155/2011/614383
Description	Keyhole limpet haemocyanin (KLH) appears to be a promising protein carrier for tumor antigens in numerous cancer vaccine candidates. The humoral immune response to KLH was characterized at the single-cell level with ELISPOT combined with separations of cell populations according to their expression of homing receptors (HRs). The analysis of HR expressions is expected to reveal the targeting of the immune response in the body. Eight orally primed and four nonprimed volunteers received KLH-vaccine subcutaneously. Circulating KLH-specific plasmablasts were found in all volunteers, 60 KLH-specific plasmablasts/10(6) PBMC in the nonprimed and 136/10(6) in the primed group. The proportion of L-selectin(+) plasmablasts proved high and integrin alpha(4)beta(+)(7) low. KLH serving as protein carrier in several vaccines, the homing profile of KLH-specific response may be applicable to the cancer antigen parts in the same vaccines. The present data reflect a systemic homing profile, which appears advantageous for the targeting of immune response to cancer vaccines. Keyhole limpet haemocyanin (KLH) appears to be a promising protein carrier for tumor antigens in numerous cancer vaccine candidates. The humoral immune response to KLH was characterized at the single-cell level with ELISPOT combined with separations of cell populations according to their expression of homing receptors (HRs). The analysis of HR expressions is expected to reveal the targeting of the immune response in the body. Eight orally primed and four nonprimed volunteers received KLH-vaccine subcutaneously. Circulating KLH-specific plasmablasts were found in all volunteers, 60 KLH-specific plasmablasts/10(6) PBMC in the nonprimed and 136/10(6) in the primed group. The proportion of L-selectin(+) plasmablasts proved high and integrin alpha(4)beta(+)(7) low. KLH serving as protein carrier in several vaccines, the homing profile of KLH-specific response may be applicable to the cancer antigen parts in the same vaccines. The present data reflect a systemic homing profile, which appears advantageous for the targeting of immune response to cancer vaccines. (en)
Title	Humoral immune response to keyhole limpet haemocyanin, the protein carrier in cancer vaccines Humoral immune response to keyhole limpet haemocyanin, the protein carrier in cancer vaccines (en)
skos:prefLabel	Humoral immune response to keyhole limpet haemocyanin, the protein carrier in cancer vaccines Humoral immune response to keyhole limpet haemocyanin, the protein carrier in cancer vaccines (en)
skos:notation	RIV/00216208:11110/11:8876!RIV12-MSM-11110___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	art.614383
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Živný, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	202996
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/11:8876
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CUTANEOUS LYMPHOCYTE ANTIGEN; ANTIBODY-SECRETING CELLS; NODE HOMING RECEPTOR; ADHESION MOLECULE; T-CELLS; B-CELLS; EXPRESSION; HUMANS; SITE; SKIN (en)
http://linked.open.../riv/klicoveSlovo	EXPRESSION HUMANS ADHESION MOLECULE ANTIBODY-SECRETING CELLS B-CELLS CUTANEOUS LYMPHOCYTE ANTIGEN NODE HOMING RECEPTOR SITE SKIN T-CELLS
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[8E77C9E0A895]
http://linked.open...i/riv/nazevZdroje	Clinical & Developmental Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	2011
http://linked.open...iv/tvurceVysledku	Živný, Jan Elson, Charles Hakkinen, Mika Kantele, Anu Kantele, Jussi Mestecký, Jiří
http://linked.open...ain/vavai/riv/wos	000293583700001
issn	1740-2522
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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