About: Diversification of fasting regulated transcription in a cluster of duplicated nuclear hormone receptors in C. elegans

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About: Diversification of fasting regulated transcription in a cluster of duplicated nuclear hormone receptors in C. elegans Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The evolutionary pressures that leads to the expansion of nuclear receptors (NHRs) in nematodes, as well as the function of the majority of them are not known. We analyzed a cluster of seven NHR genes for an analysis of their expression and function. We found that all seven genes of this cluster are expressed and five have partially overlapping expression pattern including pharynx, intestine, certain neurons, the anal sphincter muscle, and male specific cells. Four genes from this cluster are conserved between C. elegans and C. briggsae. We also found that a subset of genes in this cluster respond transcriptionally to fasting in tissue-specific patterns. These results reveal the diversification of the temporal, spatial, and metabolic gene expression patterns coupled with evolutionary drift within family of supplementary nuclear receptors. The evolutionary pressures that leads to the expansion of nuclear receptors (NHRs) in nematodes, as well as the function of the majority of them are not known. We analyzed a cluster of seven NHR genes for an analysis of their expression and function. We found that all seven genes of this cluster are expressed and five have partially overlapping expression pattern including pharynx, intestine, certain neurons, the anal sphincter muscle, and male specific cells. Four genes from this cluster are conserved between C. elegans and C. briggsae. We also found that a subset of genes in this cluster respond transcriptionally to fasting in tissue-specific patterns. These results reveal the diversification of the temporal, spatial, and metabolic gene expression patterns coupled with evolutionary drift within family of supplementary nuclear receptors. (en)
Title	Diversification of fasting regulated transcription in a cluster of duplicated nuclear hormone receptors in C. elegans Diversification of fasting regulated transcription in a cluster of duplicated nuclear hormone receptors in C. elegans (en)
skos:prefLabel	Diversification of fasting regulated transcription in a cluster of duplicated nuclear hormone receptors in C. elegans Diversification of fasting regulated transcription in a cluster of duplicated nuclear hormone receptors in C. elegans (en)
skos:notation	RIV/00216208:11110/10:7794!RIV11-GA0-11110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA304/08/0970), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Šimečková, Kateřina Vohánka, Jaroslav Kostrouchová, Marta Kostrouch, Zdeněk Behenský, František Machalová, Eliška
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	254793
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/10:7794
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Caenorhabditis elegans; Caenorhabditis briggsae; Nuclear hormone receptor; Gene expression; Fasting; early larval development; caenorhabditis-elegans; nematodes; superfamily; nhr-40 (en)
http://linked.open.../riv/klicoveSlovo	Gene expression caenorhabditis-elegans nematodes Caenorhabditis elegans Caenorhabditis briggsae Fasting Nuclear hormone receptor early larval development nhr-40 superfamily
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[5B6ECCBB8CFC]
http://linked.open...i/riv/nazevZdroje	Gene Expression Patterns
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of nuclear receptors in regulation of nematode development
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Behenský, František Kostrouch, Zdeněk Kostrouchová, Marta Machalová, Eliška Krause, Michael W. Vohánka, Jaroslav Šimečková, Kateřina
http://linked.open...ain/vavai/riv/wos	000280914300001
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	1567-133X
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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