About: Assembly factors and ATP- dependent proteases in cytochrome c oxidase biogenesis

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About: Assembly factors and ATP- dependent proteases in cytochrome c oxidase biogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cytochrome c oxidase (CcO) is the terminal enzyme of the energy-transducing mitochondrial electron transport chain. It is a hetero-oligomeric complex composed of both mitochondrially and nuclear-encoded subunits. The biogenesis of CcO is sequential process that requires numerous specific accessory proteins, so-called assembly factors, which include translational activators, translocases, molecular chaperones, copper metallochaperones and heme a biosynthetic enzymes. In addition, the correct biogenesis of CcO requires an even greater number of proteins with broader substrate specificities. Indeed, mitochondrial ATP-dependent proteases might play an important role in CcO biogenesis. Out of the four identified energy dependent mitochondrial proteases, three were shown to be involved in proteolysis of CcO subunits. Besides their protein-quality control function these oligomeric complexes may function as molecular chaperones promoting productive folding and assembly of CcO subunits. Cytochrome c oxidase (CcO) is the terminal enzyme of the energy-transducing mitochondrial electron transport chain. It is a hetero-oligomeric complex composed of both mitochondrially and nuclear-encoded subunits. The biogenesis of CcO is sequential process that requires numerous specific accessory proteins, so-called assembly factors, which include translational activators, translocases, molecular chaperones, copper metallochaperones and heme a biosynthetic enzymes. In addition, the correct biogenesis of CcO requires an even greater number of proteins with broader substrate specificities. Indeed, mitochondrial ATP-dependent proteases might play an important role in CcO biogenesis. Out of the four identified energy dependent mitochondrial proteases, three were shown to be involved in proteolysis of CcO subunits. Besides their protein-quality control function these oligomeric complexes may function as molecular chaperones promoting productive folding and assembly of CcO subunits. (en)
Title	Assembly factors and ATP- dependent proteases in cytochrome c oxidase biogenesis Assembly factors and ATP- dependent proteases in cytochrome c oxidase biogenesis (en)
skos:prefLabel	Assembly factors and ATP- dependent proteases in cytochrome c oxidase biogenesis Assembly factors and ATP- dependent proteases in cytochrome c oxidase biogenesis (en)
skos:notation	RIV/00216208:11110/10:6853!RIV11-GA0-11110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GPP305/10/P414), P(NS10581), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	6-7
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Stibůrek, Lukáš Zeman, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	247863
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/10:6853
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Mitochondria; Cytochrome c oxidase; Assembly factor; SCO1; SCO2; SURF1; TACO1; OXA1L; ATP-dependent protease; YME1L; LON; i-AAA; m-AAA (en)
http://linked.open.../riv/klicoveSlovo	Assembly factor ATP-dependent protease OXA1L SCO1 SCO2 SURF1 TACO1 i-AAA m-AAA Cytochrome c oxidase LON Mitochondria YME1L
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[5D4B1F94BBB3]
http://linked.open...i/riv/nazevZdroje	Biochimica et Biophysica Acta - Bioenergetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic bases of cytochrome c oxidase deficiency Structure-function characterization of human i-AAA protease, Yme1l1, and translocase Oxa1l in the biogenesis of the oxidative phosphorylation system
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	1797
http://linked.open...iv/tvurceVysledku	Zeman, Jiří Stibůrek, Lukáš
http://linked.open...ain/vavai/riv/wos	000279663200066
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	0005-2728
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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