About: Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development

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About: Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The mitochondrial biogenesis and adequate energy production are important for fetal growth and early postnatal adaptation. The aim of the study was to characterize mitochondrial DNA (mtDNA) content and expression patterns of POLG, TFAM, NRF1,NRF2 and PGC1 family of regulated coactivators (PGC1A, PGC1B and PRC), COX4 and MTCO2 in human fetal tissues during gestation. Moreover enzyme activities of COX and CS and protein levels of cytochrome c oxidase (COX) subunits were analysed. DNA, RNA and proteins were isolated from 26 pairs of fetal liver and muscle samples between 13th and 28th week of gestation. This work offers a broad view on the differences in expression of POLG, TFAM, NRF2 genes and family PGC1 coactivators found between the fetal tissues. The significant tissue-specific changes in expression of selected COX subunits on mRNA level were observed. The considerable differences in enzyme activities of COX and CS are demonstrated between fetal and postnatal phase. In conclusion our study indicates The mitochondrial biogenesis and adequate energy production are important for fetal growth and early postnatal adaptation. The aim of the study was to characterize mitochondrial DNA (mtDNA) content and expression patterns of POLG, TFAM, NRF1,NRF2 and PGC1 family of regulated coactivators (PGC1A, PGC1B and PRC), COX4 and MTCO2 in human fetal tissues during gestation. Moreover enzyme activities of COX and CS and protein levels of cytochrome c oxidase (COX) subunits were analysed. DNA, RNA and proteins were isolated from 26 pairs of fetal liver and muscle samples between 13th and 28th week of gestation. This work offers a broad view on the differences in expression of POLG, TFAM, NRF2 genes and family PGC1 coactivators found between the fetal tissues. The significant tissue-specific changes in expression of selected COX subunits on mRNA level were observed. The considerable differences in enzyme activities of COX and CS are demonstrated between fetal and postnatal phase. In conclusion our study indicates (en)
Title	Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development (en)
skos:prefLabel	Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development (en)
skos:notation	RIV/00216208:11110/10:6825!RIV11-MZ0-11110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0520), P(NR9410), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hájková, Zuzana Vinšová, Kamila Zeman, Jiří Honzík, Tomáš Tesařová, Markéta Magner, Martin Hůlková, Martina Hansíková, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	271602
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/10:6825
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Mitochondrial biogenesis; mtDNA; Fetal development; POLG; TFAM; NRF (en)
http://linked.open.../riv/klicoveSlovo	mtDNA Fetal development Mitochondrial biogenesis NRF POLG TFAM
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[7DBB217E7B4E]
http://linked.open...i/riv/nazevZdroje	Mitochondrion
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Applied Genomics Biochemical and molecular basis of mitochondrial energetic metabolism in neonates
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Hájková, Zuzana Havlíčková, Vendula Honzík, Tomáš Magner, Martin Tesařová, Markéta Zeman, Jiří Hůlková, Martina Hansíková, Hana Vinšová, Kamila
http://linked.open...ain/vavai/riv/wos	000278262600003
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	1567-7249
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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