About: Head and neck squamous cancer stromal fibroblasts produce growth factors influencing phenotype of normal human keratinocytes

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Epithelial–mesenchymal interaction between stromal fibroblasts and cancer cells influences the functional properties of tumor epithelium, including the tumor progression and spread. We compared fibroblasts prepared from stroma of squamous cell carcinoma and normal dermal fibroblasts concerning their biological activity toward normal keratinocytes assessed by immunocytochemistry and profiling of gene activation for growth factors/cytokines by microarray chip technology. IGF-2 and BMP-4 were determined as candidate factors responsible for tumor-associated fibroblast activity that influences normal epithelia. This effect was confirmed by addition of recombinant IGF-2 and BMP4, respectively, to the culture medium. This hypothesis was also verified by inhibition experiments where blocking antibodies were employed in the medium conditioned by cancer-associated fibroblast. Presence of these growth factors was also detected in tumor samples. Epithelial–mesenchymal interaction between stromal fibroblasts and cancer cells influences the functional properties of tumor epithelium, including the tumor progression and spread. We compared fibroblasts prepared from stroma of squamous cell carcinoma and normal dermal fibroblasts concerning their biological activity toward normal keratinocytes assessed by immunocytochemistry and profiling of gene activation for growth factors/cytokines by microarray chip technology. IGF-2 and BMP-4 were determined as candidate factors responsible for tumor-associated fibroblast activity that influences normal epithelia. This effect was confirmed by addition of recombinant IGF-2 and BMP4, respectively, to the culture medium. This hypothesis was also verified by inhibition experiments where blocking antibodies were employed in the medium conditioned by cancer-associated fibroblast. Presence of these growth factors was also detected in tumor samples. (en)
Title	Head and neck squamous cancer stromal fibroblasts produce growth factors influencing phenotype of normal human keratinocytes Head and neck squamous cancer stromal fibroblasts produce growth factors influencing phenotype of normal human keratinocytes (en)
skos:prefLabel	Head and neck squamous cancer stromal fibroblasts produce growth factors influencing phenotype of normal human keratinocytes Head and neck squamous cancer stromal fibroblasts produce growth factors influencing phenotype of normal human keratinocytes (en)
skos:notation	RIV/00216208:11110/10:6295!RIV11-GA0-11110___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(2B06106), P(GP304/08/P175), Z(AV0Z50520514), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Smetana, Karel Dvořánková, Barbora Valach, Jaroslav Lacina, Lukáš Betka, Jan Plzák, Jan Chovanec, Martin Čada, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	261267
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/10:6295
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cancer microenvironment; Epithelial-mesenchymal interaction; Cancer-associated fibroblasts (en)
http://linked.open.../riv/klicoveSlovo	Cancer microenvironment Cancer-associated fibroblasts Epithelial-mesenchymal interaction
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[953CD1D0FD4E]
http://linked.open...i/riv/nazevZdroje	Histochemistry and Cell Biology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Novel genomic and biotechlological approaches in molecular oncology: a way to the early diagnostics and targeted therapy Multifenotype profiling of head and neck squamous cell carcinomas - study of stem cell properties
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	133
http://linked.open...iv/tvurceVysledku	Dvořánková, Barbora Kolář, Michal Lacina, Lukáš Smetana, Karel Strnad, Hynek Valach, Jaroslav Vlček, Čestmír Čada, Zdeněk Urbanová, Markéta Betka, Jan Chovanec, Martin Plzák, Jan Šáchová, Jana
http://linked.open...ain/vavai/riv/wos	000273745800006
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	0948-6143
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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