About: Genome analysis and comparative genomics of a Giardia intestinalis assemblage E isolate

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About: Genome analysis and comparative genomics of a Giardia intestinalis assemblage E isolate Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	To further understand the genetic diversity between the Giardia intestinalis species, we have performed genome sequencing and analysis of a wild-type sample from the assemblage E. We identified 5012 protein coding genes, the majority of which are conserved in terms of microsynteny and sequence identity. Despite this, there is an unexpectedly large number of chromosomal rearrangements and several smaller structural changes present in all chromosomes. Novel members of the VSP, NEK Kinase and HCMP gene families were identified, which may reveal possible mechanisms for host specificity and new avenues for antigenic variation. Extensive analyses of polymorphisms in the core proteome of Giardia revealed differential rates of divergence among cellular processes. Our results indicate that despite a well conserved core of genes there is significant genome variation between Giardia isolates, both in terms of gene content, gene polymorphisms, structural chromosomal variations and surface molecule repertoires. To further understand the genetic diversity between the Giardia intestinalis species, we have performed genome sequencing and analysis of a wild-type sample from the assemblage E. We identified 5012 protein coding genes, the majority of which are conserved in terms of microsynteny and sequence identity. Despite this, there is an unexpectedly large number of chromosomal rearrangements and several smaller structural changes present in all chromosomes. Novel members of the VSP, NEK Kinase and HCMP gene families were identified, which may reveal possible mechanisms for host specificity and new avenues for antigenic variation. Extensive analyses of polymorphisms in the core proteome of Giardia revealed differential rates of divergence among cellular processes. Our results indicate that despite a well conserved core of genes there is significant genome variation between Giardia isolates, both in terms of gene content, gene polymorphisms, structural chromosomal variations and surface molecule repertoires. (en)
Title	Genome analysis and comparative genomics of a Giardia intestinalis assemblage E isolate Genome analysis and comparative genomics of a Giardia intestinalis assemblage E isolate (en)
skos:prefLabel	Genome analysis and comparative genomics of a Giardia intestinalis assemblage E isolate Genome analysis and comparative genomics of a Giardia intestinalis assemblage E isolate (en)
skos:notation	RIV/00216208:11110/10:6157!RIV11-MSM-11110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	543
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Nohýnková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	260464
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/10:6157
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Giardia intestinalis; assemblage E; genome; comparative genomics; core proteome (en)
http://linked.open.../riv/klicoveSlovo	comparative genomics genome Giardia intestinalis assemblage E core proteome
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E00CBFCFD930]
http://linked.open...i/riv/nazevZdroje	BMC Genomics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Nohýnková, Eva Anderson, Bjorn Anderson, Jan O Ankarklev, Johan Franzén, Oscar Jerlström-Hultqvist, Jon Svärd, Staffan G Xu, Feifei
http://linked.open...ain/vavai/riv/wos	000283123400001
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	1471-2164
number of pages	15 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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