About: Oxidative DNA damage in bone marrow cells of patients with low-risk myelodysplastic syndrome

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About: Oxidative DNA damage in bone marrow cells of patients with low-risk myelodysplastic syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bone marrow aspirates of 19 patients with low-risk myelodysplastic syndromes (MDS) and 14 control subjects were collected in order to assess the level of oxidative DNA damage. Glycophorin A positive and negative cells separated by miniMACS magnetic cell sorting were subjected to single cell gel electrophoresis (comet assay) combined with enzymes of base excision repair (endonuclease III and formamido-pyrimidine-glycosylase) that specifically recognize oxidized nucleotides. Compared to controls, MDS patients exhibited a significant increase of oxidative damage to DNA which could contribute to genomic instability and disease progression. Bone marrow aspirates of 19 patients with low-risk myelodysplastic syndromes (MDS) and 14 control subjects were collected in order to assess the level of oxidative DNA damage. Glycophorin A positive and negative cells separated by miniMACS magnetic cell sorting were subjected to single cell gel electrophoresis (comet assay) combined with enzymes of base excision repair (endonuclease III and formamido-pyrimidine-glycosylase) that specifically recognize oxidized nucleotides. Compared to controls, MDS patients exhibited a significant increase of oxidative damage to DNA which could contribute to genomic instability and disease progression. (en)
Title	Oxidative DNA damage in bone marrow cells of patients with low-risk myelodysplastic syndrome Oxidative DNA damage in bone marrow cells of patients with low-risk myelodysplastic syndrome (en)
skos:prefLabel	Oxidative DNA damage in bone marrow cells of patients with low-risk myelodysplastic syndrome Oxidative DNA damage in bone marrow cells of patients with low-risk myelodysplastic syndrome (en)
skos:notation	RIV/00216208:11110/09:5810!RIV10-MZ0-11110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR8265), Z(AV0Z50390512), Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Neuwirtová, Radana Šišková, Magda
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	332480
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/09:5810
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Myelodysplastic syndrome; Refractory anemia; Refractory anemia with ring sideroblasts; Oxidative DNA damage; Comet assay (en)
http://linked.open.../riv/klicoveSlovo	Comet assay Myelodysplastic syndrome Oxidative DNA damage Refractory anemia Refractory anemia with ring sideroblasts
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[ECF2A74C4A2E]
http://linked.open...i/riv/nazevZdroje	Leukemia Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Oxidative damage of DNA in bone marrow cells of patients with myelodysplastic syndrome - subtype refractory anemia with or without ring sideroblasts.
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Novotná, B. Neuwirtová, Radana Šišková, Magda Bagryantseva, Y.
http://linked.open...ain/vavai/riv/wos	000262576400023
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	0145-2126
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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