About: Studies on distribution and metabolism of para-methoxymethamphetamine (PMMA) designer drug in rats using gas chromatography-mass spectrometry

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About: Studies on distribution and metabolism of para-methoxymethamphetamine (PMMA) designer drug in rats using gas chromatography-mass spectrometry Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Para-Methoxymethamphetamine (PMMA) is an abused psychedelic compound with reports of several intoxications and deaths after ingestion. However, its pharmacokinetics based on a controlled study is unknown and only partial information on its biotransformation is available. Our experimental study was designed for the time disposition profile of PMMA and its metabolites para-methoxyamphetamine (PMA), para-hydroxymethamphetamine (OH-MAM) and para-hydroxyamphetamine (OH-AM) in blood and biological tissues in rats after the bolus subcutaneous dose 40 mg/kg using a validated GC-MS method. The experimental results ascertained could be useful for subsequent evaluation of PMMA psychotropic or neurotoxic effects and the diagnostic concern of intoxication. Para-Methoxymethamphetamine (PMMA) is an abused psychedelic compound with reports of several intoxications and deaths after ingestion. However, its pharmacokinetics based on a controlled study is unknown and only partial information on its biotransformation is available. Our experimental study was designed for the time disposition profile of PMMA and its metabolites para-methoxyamphetamine (PMA), para-hydroxymethamphetamine (OH-MAM) and para-hydroxyamphetamine (OH-AM) in blood and biological tissues in rats after the bolus subcutaneous dose 40 mg/kg using a validated GC-MS method. The experimental results ascertained could be useful for subsequent evaluation of PMMA psychotropic or neurotoxic effects and the diagnostic concern of intoxication. (en)
Title	Studies on distribution and metabolism of para-methoxymethamphetamine (PMMA) designer drug in rats using gas chromatography-mass spectrometry Studies on distribution and metabolism of para-methoxymethamphetamine (PMMA) designer drug in rats using gas chromatography-mass spectrometry (en)
skos:prefLabel	Studies on distribution and metabolism of para-methoxymethamphetamine (PMMA) designer drug in rats using gas chromatography-mass spectrometry Studies on distribution and metabolism of para-methoxymethamphetamine (PMMA) designer drug in rats using gas chromatography-mass spectrometry (en)
skos:notation	RIV/00216208:11110/09:5253!RIV10-MZ0-11110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR8332)
http://linked.open...iv/cisloPeriodika	S1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Balíková, Marie Rohanová, Miroslava
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	344354
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/09:5253
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PMMA; p-Methoxymethamfetamine; GC-MS assay; Disposition; Metabolism; Rats (en)
http://linked.open.../riv/klicoveSlovo	Disposition Metabolism Rats GC-MS assay p-Methoxymethamfetamine PMMA
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[7581B8AFEAA6]
http://linked.open...i/riv/nazevZdroje	Legal Medicine
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of metabolism of synthetic psychedelic amines as new toxic agents in clinical and forensic toxicology
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Balíková, Marie Rohanová, Miroslava
issn	1344-6223
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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