About: The biological environment of Hodgkin's lymphoma and the role of the chemokine CCL17/TARC

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About: The biological environment of Hodgkin's lymphoma and the role of the chemokine CCL17/TARC Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Hodgkin's lymphoma is a lymphoproliferative disease, which differs in its morphology and therapeutic response from other lymphomas. Neoplastic cells represent only a minor cell population of the tumour, while the major part of the tumour is formed by inflammatory cells. It results from the production of cytokines and chemokines both by neoplastic cells and by inflammatory cells. An important prognostic marker in Hodgkin’s lymphoma appears to be the chemokine (C-C motif) ligand 17 (CCL17), also known as thymus and activation-related chemokine (TARC). This chemokine is expressed by many cell types and tissues, and in the case of Hodgkin lymphoma, also by Reed-Sternberg cells. CCL17/TARC binds to chemokine receptors CCR4 and CCR8 and displays chemotactic activity for T lymphocytes and some other leukocytes. The understanding of biological pathways in Hodgkin’s lymphoma could be important for monitoring of disease activity and for the development of future targeted therapy. Hodgkin's lymphoma is a lymphoproliferative disease, which differs in its morphology and therapeutic response from other lymphomas. Neoplastic cells represent only a minor cell population of the tumour, while the major part of the tumour is formed by inflammatory cells. It results from the production of cytokines and chemokines both by neoplastic cells and by inflammatory cells. An important prognostic marker in Hodgkin’s lymphoma appears to be the chemokine (C-C motif) ligand 17 (CCL17), also known as thymus and activation-related chemokine (TARC). This chemokine is expressed by many cell types and tissues, and in the case of Hodgkin lymphoma, also by Reed-Sternberg cells. CCL17/TARC binds to chemokine receptors CCR4 and CCR8 and displays chemotactic activity for T lymphocytes and some other leukocytes. The understanding of biological pathways in Hodgkin’s lymphoma could be important for monitoring of disease activity and for the development of future targeted therapy. (en)
Title	The biological environment of Hodgkin's lymphoma and the role of the chemokine CCL17/TARC The biological environment of Hodgkin's lymphoma and the role of the chemokine CCL17/TARC (en)
skos:prefLabel	The biological environment of Hodgkin's lymphoma and the role of the chemokine CCL17/TARC The biological environment of Hodgkin's lymphoma and the role of the chemokine CCL17/TARC (en)
skos:notation	RIV/00216208:11110/09:3859!RIV10-MSM-11110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Živný, Jan Trněný, Marek Móciková, H.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	305178
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/09:3859
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Hodgkin's lymphoma; HRC cells; chemokine; CCL17/TARC (en)
http://linked.open.../riv/klicoveSlovo	CCL17/TARC HRC cells Hodgkin's lymphoma chemokine
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[D46B17E0E1FD]
http://linked.open...i/riv/nazevZdroje	Prague Medical Report
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	110
http://linked.open...iv/tvurceVysledku	Trněný, Marek Živný, Jan Móciková, Heidi Hnátková, Markéta
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	1214-6994
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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