About: Changes in the localization of collagens IV and VIII in corneas obtained from patients with posterior polymorphous corneal dystrophy

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About: Changes in the localization of collagens IV and VIII in corneas obtained from patients with posterior polymorphous corneal dystrophy Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this study was to determine the changes in the presence and localization of the α1 – α6 collagen IV and α1, α2 collagen VIII chains in Czech patients with posterior polymorphous corneal dystrophy (PPCD). Twelve corneal buttons from ten PPCD patients as well as eight control corneas were used and enzymatic indirect immunohistochemistry was performed. More than 50% of PPCD specimens exhibited positivity for α1 and α2 collagen IV chains in the basal membrane of the epithelium and in the posterior stroma, while no staining was detected in controls. The α1 collagen VIII chain was detected on the endothelial and stromal sides of Descemet’s membrane (DM), compared with the prevailing localization on the stromal side of DM in control corneas. The increased expression and the change in localization of the α1, α2 collagen IV and α1 collagen VIII chains may contribute to the increased endothelial proliferative capacity observed in PPCD patients. The aim of this study was to determine the changes in the presence and localization of the α1 – α6 collagen IV and α1, α2 collagen VIII chains in Czech patients with posterior polymorphous corneal dystrophy (PPCD). Twelve corneal buttons from ten PPCD patients as well as eight control corneas were used and enzymatic indirect immunohistochemistry was performed. More than 50% of PPCD specimens exhibited positivity for α1 and α2 collagen IV chains in the basal membrane of the epithelium and in the posterior stroma, while no staining was detected in controls. The α1 collagen VIII chain was detected on the endothelial and stromal sides of Descemet’s membrane (DM), compared with the prevailing localization on the stromal side of DM in control corneas. The increased expression and the change in localization of the α1, α2 collagen IV and α1 collagen VIII chains may contribute to the increased endothelial proliferative capacity observed in PPCD patients. (en)
Title	Changes in the localization of collagens IV and VIII in corneas obtained from patients with posterior polymorphous corneal dystrophy Changes in the localization of collagens IV and VIII in corneas obtained from patients with posterior polymorphous corneal dystrophy (en)
skos:prefLabel	Changes in the localization of collagens IV and VIII in corneas obtained from patients with posterior polymorphous corneal dystrophy Changes in the localization of collagens IV and VIII in corneas obtained from patients with posterior polymorphous corneal dystrophy (en)
skos:notation	RIV/00216208:11110/09:3501!RIV10-MSM-11110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Jirsová, Kateřina Lišková, Petra Merjavá, Stanislava
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	306674
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/09:3501
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	posterior; polymorphous; cornea; dystrophy; collagen IV; collagen VIII; cornea; immunohistochemistry (en)
http://linked.open.../riv/klicoveSlovo	immunohistochemistry cornea polymorphous posterior collagen IV collagen VIII dystrophy
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[EDDA64454B42]
http://linked.open...i/riv/nazevZdroje	Experimental Eye Research
http://linked.open...in/vavai/riv/obor	FF
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	88
http://linked.open...iv/tvurceVysledku	Lišková, Petra Jirsová, Kateřina Merjavá, Stanislava Davis, Paul F. Greenhill, Nicholas S. Sado, Yoshikazu
http://linked.open...ain/vavai/riv/wos	000265898400011
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	0014-4835
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11110

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