About: Double heterozygotes for ACE ID and AGT M235t polymorphisms are in lower risk of developing non-syndromic intrauterine growth restriction: a possible role of appetite?

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About: Double heterozygotes for ACE ID and AGT M235t polymorphisms are in lower risk of developing non-syndromic intrauterine growth restriction: a possible role of appetite? Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	https://www.novapublishers.com/catalog/product_info.php?products_id=48036&osCsid=b
Description	The ftal origin of civilization disorders concept favors the idea of prenatal programming of adult age diseases such as hypertension. Patients with advanced chronic heart failure or other and-stage diseases often have increased AngII levels and cachexia, and angiotensin-converting enzyme (ACE) inhibitor treatment improves weight loss. In this cross-sectional association study, we investigated possible associations of ACE ID and AGT M235T polymorphisms with occurence of idiopathic, non-syndromic intrauterine growth restriction (IUGR) and/or preeclampsia. No significant differences in single genotype distributions or allelic frequencies of both ACE ID and AGT M235T polymorphisms were observed between studied cohorts. However, the double heterozygosity (ID/MT) was significantly associated with lower prevalence of IUGR. The single genotypes for ACE ID or AGT M235T genes do not seem to increase the risk of preeclampsia or IUGR in pregnanacy. Despite the small sample size, the present study supports the idea of protective effect of combined heterozygotes (ID/MT) against the IUGR development risk. The ftal origin of civilization disorders concept favors the idea of prenatal programming of adult age diseases such as hypertension. Patients with advanced chronic heart failure or other and-stage diseases often have increased AngII levels and cachexia, and angiotensin-converting enzyme (ACE) inhibitor treatment improves weight loss. In this cross-sectional association study, we investigated possible associations of ACE ID and AGT M235T polymorphisms with occurence of idiopathic, non-syndromic intrauterine growth restriction (IUGR) and/or preeclampsia. No significant differences in single genotype distributions or allelic frequencies of both ACE ID and AGT M235T polymorphisms were observed between studied cohorts. However, the double heterozygosity (ID/MT) was significantly associated with lower prevalence of IUGR. The single genotypes for ACE ID or AGT M235T genes do not seem to increase the risk of preeclampsia or IUGR in pregnanacy. Despite the small sample size, the present study supports the idea of protective effect of combined heterozygotes (ID/MT) against the IUGR development risk. (en)
Title	Double heterozygotes for ACE ID and AGT M235t polymorphisms are in lower risk of developing non-syndromic intrauterine growth restriction: a possible role of appetite? Double heterozygotes for ACE ID and AGT M235t polymorphisms are in lower risk of developing non-syndromic intrauterine growth restriction: a possible role of appetite? (en)
skos:prefLabel	Double heterozygotes for ACE ID and AGT M235t polymorphisms are in lower risk of developing non-syndromic intrauterine growth restriction: a possible role of appetite? Double heterozygotes for ACE ID and AGT M235t polymorphisms are in lower risk of developing non-syndromic intrauterine growth restriction: a possible role of appetite? (en)
skos:notation	RIV/00209805:_____/14:#0000592!RIV15-MSM-00209805
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0101), Z(MZ0MOU2005)
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Bienertová-Vašků, Julie
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	12299
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/14:#0000592
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	preeclampsia; ACE ID and AGT M235t polymorphisms; pregnancy (en)
http://linked.open.../riv/klicoveSlovo	ACE ID and AGT M235t polymorphisms pregnancy preeclampsia
http://linked.open...ontrolniKodProRIV	[321E24DC5C6A]
http://linked.open...i/riv/mistoVydani	New York
http://linked.open...i/riv/nazevZdroje	Appetite: regulation, use of stimulants and cultural and biological influences
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...v/pocetStranKnihy	228 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Regional Centre for Applied Molecular Oncology (RECAMO)
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Bienertová-Vašků, Julie
http://linked.open...n/vavai/riv/zamer	Functional diagnostics of malignant tumours
number of pages	11 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Nova Science Publishers
https://schema.org/isbn	978-1-63117-241-0

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