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  • Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 1 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs11116446171 at 6p25.3 (EXOC2; P = 2.33 x 10-21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10-10), rs79480871 1 at 2p23.3 (NCOA1; P = 4.23 x 10-8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 1 (PVT1; P = 9.98 x 10-13 and 3.63 x 10-11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
  • Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 1 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs11116446171 at 6p25.3 (EXOC2; P = 2.33 x 10-21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10-10), rs79480871 1 at 2p23.3 (NCOA1; P = 4.23 x 10-8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 1 (PVT1; P = 9.98 x 10-13 and 3.63 x 10-11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL. (en)
Title
  • Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
  • Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma (en)
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  • Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
  • Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma (en)
skos:notation
  • RIV/00209805:_____/14:#0000575!RIV15-MSM-00209805
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  • I, P(ED2.1.00/03.0101)
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  • 11
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  • 18142
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  • RIV/00209805:_____/14:#0000575
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  • SNP; HLA variants; meta-analysis (en)
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  • CZ - Česká republika
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  • [2A69C8309872]
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  • Nature genetics
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  • 46
http://linked.open...iv/tvurceVysledku
  • Foretová, Lenka
  • Cerhan, James R.
issn
  • 1061-4036
number of pages
http://bibframe.org/vocab/doi
  • 10.1038/ng.3105
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