About: Chaperones and evolution

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.mzm.cz/fileadmin/user_upload/publikace/casopisy/fm_49_2_2013/fm-2-2013-abstract-10.pdf
Description	Phenotypic robustness is enabled by several mechanisms masking detrimental genetic variations in individuals. These mechanisms involve gene duplication and functional redundancy of cellular pathways. Recently the role of Hsp90 chaperone system was suggested in the process of buffering genetic variation on the protein level. This activity of chaperones has a profound effect on the accumulation of large numbers of phenotypically silent genotypes and thus may play an important role in evolution. Phenotypic robustness is enabled by several mechanisms masking detrimental genetic variations in individuals. These mechanisms involve gene duplication and functional redundancy of cellular pathways. Recently the role of Hsp90 chaperone system was suggested in the process of buffering genetic variation on the protein level. This activity of chaperones has a profound effect on the accumulation of large numbers of phenotypically silent genotypes and thus may play an important role in evolution. (en)
Title	Chaperones and evolution Chaperones and evolution (en)
skos:prefLabel	Chaperones and evolution Chaperones and evolution (en)
skos:notation	RIV/00209805:_____/13:#0000447!RIV14-MZ0-00209805
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0101)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Müller, Petr Vojtěšek, Bořivoj Trčka, Filip
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	64999
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/13:#0000447
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Hsp90; folding; genetic variation (en)
http://linked.open.../riv/klicoveSlovo	genetic variation folding Hsp90
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[0FE17BB5F6DC]
http://linked.open...i/riv/nazevZdroje	Folia Mendeliana
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Regional Centre for Applied Molecular Oncology (RECAMO)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	49
http://linked.open...iv/tvurceVysledku	Vojtěšek, Bořivoj Müller, Petr Trčka, Filip
issn	0085-0748
number of pages	4 (xsd:int)

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