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rdf:type
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rdfs:seeAlso
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Description
| - Dihydropyrimidine dehydrogenase is a key enzyme involved in the metabolism of fluoropyrimidine anticancer drugs. Several studies have demonstrated that diminished DPD activity as a consequence of genetic variations in the DPYD gene limits carrier´s ability to fully metabolize the drug, resulting in toxicity and adverse events. DPYD*2A (IVS14+1G > A) represents the most abundant variant allele in the European Caucasian population. Cancer patients with this gene variant represent a subgroup with higher risk of toxicity when treated with fluoropyrimidines. Therefore, we have implemented a method for DPYD*2A allele genotyping. In our pilot study performed in a group of individuals derived from our regional reference population, we found that none out of 47 subjects was a carrier of the DPYD*2A variant allele.
- Dihydropyrimidine dehydrogenase is a key enzyme involved in the metabolism of fluoropyrimidine anticancer drugs. Several studies have demonstrated that diminished DPD activity as a consequence of genetic variations in the DPYD gene limits carrier´s ability to fully metabolize the drug, resulting in toxicity and adverse events. DPYD*2A (IVS14+1G > A) represents the most abundant variant allele in the European Caucasian population. Cancer patients with this gene variant represent a subgroup with higher risk of toxicity when treated with fluoropyrimidines. Therefore, we have implemented a method for DPYD*2A allele genotyping. In our pilot study performed in a group of individuals derived from our regional reference population, we found that none out of 47 subjects was a carrier of the DPYD*2A variant allele. (en)
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Title
| - Detection of DPYD*2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients
- Detection of DPYD*2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients (en)
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skos:prefLabel
| - Detection of DPYD*2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients
- Detection of DPYD*2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients (en)
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skos:notation
| - RIV/00209805:_____/13:#0000446!RIV14-MZ0-00209805
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(ED2.1.00/03.0101), P(LM2010004)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00209805:_____/13:#0000446
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - DPD genotyping; polymorphism; fluoropyrimidines; toxicity (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Valík, Dalibor
- Mrkvicová, Martina
- Pilátová, Kateřina
- Zdražilová Dubská, Lenka
- Obermannová, Radka
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issn
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number of pages
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