About: A mini review of organometallic compounds and their anticancer properties

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About: A mini review of organometallic compounds and their anticancer properties Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.mzm.cz/fileadmin/user_upload/publikace/casopisy/fm_49_2_2013/fm-2-2013-abstract-05.pdf
Description	Chemistry of organometallic compounds is a rapidly developing research area. In comparison with purely organic compounds, organometallic compounds show unique chemical properties including structural diversity, variety of available interactions, possibility of ligand exchange and redox and catalytic properties that can be used for medical purposes. The discovery of antitumor properties of cisplatin in 1979 by Rosenberg and its introduction to oncology brought a lot of interest in metal complexes chemistry containing other transition metals. Regardless of severe side-effects and frequent development of tumor resistance, cisplatin, oxaliplatin and carboplatin are still the most successful anticancer compounds. Nevertheless, it is essential to search for novel anticancer drugs with different modes of action, better selectivity and less side-effects. Organometallic compounds represent a new opportunity to achieve this goal. Chemistry of organometallic compounds is a rapidly developing research area. In comparison with purely organic compounds, organometallic compounds show unique chemical properties including structural diversity, variety of available interactions, possibility of ligand exchange and redox and catalytic properties that can be used for medical purposes. The discovery of antitumor properties of cisplatin in 1979 by Rosenberg and its introduction to oncology brought a lot of interest in metal complexes chemistry containing other transition metals. Regardless of severe side-effects and frequent development of tumor resistance, cisplatin, oxaliplatin and carboplatin are still the most successful anticancer compounds. Nevertheless, it is essential to search for novel anticancer drugs with different modes of action, better selectivity and less side-effects. Organometallic compounds represent a new opportunity to achieve this goal. (en)
Title	A mini review of organometallic compounds and their anticancer properties A mini review of organometallic compounds and their anticancer properties (en)
skos:prefLabel	A mini review of organometallic compounds and their anticancer properties A mini review of organometallic compounds and their anticancer properties (en)
skos:notation	RIV/00209805:_____/13:#0000442!RIV14-MZ0-00209805
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0101)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hrstka, Roman Vojtěšek, Bořivoj Koubková, Lucie Vyzula, Rostislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	58743
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/13:#0000442
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ferrocenes; titanocenes; cytotoxic effect (en)
http://linked.open.../riv/klicoveSlovo	cytotoxic effect ferrocenes titanocenes
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[147BF2DCD630]
http://linked.open...i/riv/nazevZdroje	Folia Mendeliana
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Regional Centre for Applied Molecular Oncology (RECAMO)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	49
http://linked.open...iv/tvurceVysledku	Hrstka, Roman Koubková, Lucie Vojtěšek, Bořivoj Vyzula, Rostislav
issn	0085-0748
number of pages	5 (xsd:int)

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