About: AGR2 predicts tamoxifen resistance in postmenopausal breast cancer patients

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1155/2013/761537
Description	Endocrine resistance is a significant problem in breast cancer treatment. Thus identification and validation of novel resistance determinants is important to improve treatment efficacy and patient outcome. In our work, AGR2 expression was determined by qRT-PCR in Tru-Cut needle biopsies from tamoxifen-treated postmenopausal breast cancer patients. Our results showed inversed association of AGR2 mRNA levels with primary treatment response (P = 0.0011) and progression-free survival (P = 0.0366) in 61 ER-positive breast carcinomas. As shown by our experimental and clinical evaluations, elevated AGR2 expression predicts decreased efficacy of tamoxifen treatment. From this perspective, AGR2 is a potential predictive biomarker enabling selection of an optimal algorithm for adjuvant hormonal therapy in postmenopausal ER-positive breast cancer patients. Endocrine resistance is a significant problem in breast cancer treatment. Thus identification and validation of novel resistance determinants is important to improve treatment efficacy and patient outcome. In our work, AGR2 expression was determined by qRT-PCR in Tru-Cut needle biopsies from tamoxifen-treated postmenopausal breast cancer patients. Our results showed inversed association of AGR2 mRNA levels with primary treatment response (P = 0.0011) and progression-free survival (P = 0.0366) in 61 ER-positive breast carcinomas. As shown by our experimental and clinical evaluations, elevated AGR2 expression predicts decreased efficacy of tamoxifen treatment. From this perspective, AGR2 is a potential predictive biomarker enabling selection of an optimal algorithm for adjuvant hormonal therapy in postmenopausal ER-positive breast cancer patients. (en)
Title	AGR2 predicts tamoxifen resistance in postmenopausal breast cancer patients AGR2 predicts tamoxifen resistance in postmenopausal breast cancer patients (en)
skos:prefLabel	AGR2 predicts tamoxifen resistance in postmenopausal breast cancer patients AGR2 predicts tamoxifen resistance in postmenopausal breast cancer patients (en)
skos:notation	RIV/00209805:_____/13:#0000428!RIV14-GA0-00209805
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0101), P(GA13-00956S), P(NT13794)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hrstka, Roman Brychtová, Veronika Vojtěšek, Bořivoj Svoboda, Marek Fabian, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	59777
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/13:#0000428
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	protein anterior gradient-2; estrogen-receptor; human homolog; expression; pathway; antigen; gene (en)
http://linked.open.../riv/klicoveSlovo	antigen pathway estrogen-receptor human homolog protein anterior gradient-2 expression gene
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[917C7AC3CD44]
http://linked.open...i/riv/nazevZdroje	Disease Markers
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Emerging roles for the proteins of Anterior Gradient family in cancer development Regional Centre for Applied Molecular Oncology (RECAMO) The analysis of chaperone system and identification of new biomarkers associated with gynecological malignancies
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Brychtová, Veronika Hrstka, Roman Vojtěšek, Bořivoj Svoboda, Marek Fabian, Pavel
http://linked.open...ain/vavai/riv/wos	000324981400001
issn	0278-0240
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1155/2013/761537

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