About: Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses

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About: Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.molecular-cancer.com/content/12/1/93
Description	Abnormal rates of growth together with metastatic potential and lack of susceptibility to cellular signals leading to apoptosis are widely investigated characteristics of tumors that develop via genetic or epigenetic mechanisms. Moreover, in the growing tumor, cells are exposed to insufficient nutrient supply, low oxygen availability (hypoxia) and/or reactive oxygen species. These physiological stresses force them to switch into more adaptable and aggressive phenotypes. This paper summarizes the role of two key mediators of cellular stress responses, namely p53 and HIF, which significantly affect cancer progression and compromise treatment outcomes. Furthermore, it describes cross-talk between these factors. Abnormal rates of growth together with metastatic potential and lack of susceptibility to cellular signals leading to apoptosis are widely investigated characteristics of tumors that develop via genetic or epigenetic mechanisms. Moreover, in the growing tumor, cells are exposed to insufficient nutrient supply, low oxygen availability (hypoxia) and/or reactive oxygen species. These physiological stresses force them to switch into more adaptable and aggressive phenotypes. This paper summarizes the role of two key mediators of cellular stress responses, namely p53 and HIF, which significantly affect cancer progression and compromise treatment outcomes. Furthermore, it describes cross-talk between these factors. (en)
Title	Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses (en)
skos:prefLabel	Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses (en)
skos:notation	RIV/00209805:_____/13:#0000424!RIV14-GA0-00209805
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0101), P(GA13-00956S), P(GBP206/12/G151)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hrstka, Roman Vojtěšek, Bořivoj Obacz, Joanna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	67354
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/13:#0000424
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	p53; HIF-1; Hypoxia; DNA damage; cancer (en)
http://linked.open.../riv/klicoveSlovo	HIF-1 Hypoxia DNA damage cancer p53
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0532EAC40410]
http://linked.open...i/riv/nazevZdroje	Molecular Cancer
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of novel approaches to bioanalysis and molecular diagnostics Emerging roles for the proteins of Anterior Gradient family in cancer development Regional Centre for Applied Molecular Oncology (RECAMO)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Hrstka, Roman Vojtěšek, Bořivoj Obacz, Joanna
http://linked.open...ain/vavai/riv/wos	000324067200001
issn	1476-4598
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/1476-4598-12-93

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