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Description
  • Multiple myeloma (MM) is an incurable plasma cell malignancy accounting for 2% of cancer-related deaths worldwide. Ethnic and population variation as well as some evidence of familial clustering indicates a genetic component to myeloma aetiology. We hypothesized that germline variation at the 8q24 locus may affect the risk of acquiring MM. In order to test this hypothesis, we genotyped six single nucleotide polymorphisms (SNPs) in a study of 424 cases and 429 controls. Subjects were recruited from the Epilymph study and the Irish myeloma study.
  • Multiple myeloma (MM) is an incurable plasma cell malignancy accounting for 2% of cancer-related deaths worldwide. Ethnic and population variation as well as some evidence of familial clustering indicates a genetic component to myeloma aetiology. We hypothesized that germline variation at the 8q24 locus may affect the risk of acquiring MM. In order to test this hypothesis, we genotyped six single nucleotide polymorphisms (SNPs) in a study of 424 cases and 429 controls. Subjects were recruited from the Epilymph study and the Irish myeloma study. (en)
Title
  • Genetic variation at the 8q24 locus confers risk to multiple myeloma
  • Genetic variation at the 8q24 locus confers risk to multiple myeloma (en)
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  • Genetic variation at the 8q24 locus confers risk to multiple myeloma
  • Genetic variation at the 8q24 locus confers risk to multiple myeloma (en)
skos:notation
  • RIV/00209805:_____/12:#0000359!RIV13-MZ0-00209805
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  • 137925
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  • RIV/00209805:_____/12:#0000359
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  • multiple myeloma; germline variation; susceptibility; single nucleotide polymorphisms; aetiology (en)
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  • US - Spojené státy americké
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  • [D1F7A1A7E7BC]
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  • British journal of haematology
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  • 156
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  • Foretová, Lenka
  • Tewari, Prerna
http://linked.open...ain/vavai/riv/wos
  • 000298058100015
issn
  • 0007-1048
number of pages
http://bibframe.org/vocab/doi
  • 10.1111/j.1365-2141.2011.08798.x
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