About: Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer

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About: Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com.proxy.mzk.cz/doi/10.1111/j.1582-4934.2011.01359.x/abstract;jsessionid=6D4726C6A71792EA6E3C6B4F149937B4.d04t01
Description	MicroRNAs (miRNAs) are small non-coding RNAs, which regulate gene expression. Single nucleotide polymorphisms (SNPs) may occur in miRNA biogenesis pathway genes, primary miRNA, pre-miRNA or a mature miRNA sequence. Such polymorphisms may be functional with respect to biogenesis and actions of mature miRNA. Specific SNPs were identified in predicted miRNA target sites within 3' untranslated regions of mRNAs. These SNPs have a potential to affect the efficiency of miRNA binding to the target sites or can create or disrupt binding sites. Resulting gene dysregulation may involve changes in phenotype and may eventually prove critical for the susceptibility to cancer and its onset as well as for estimates of prognosis and therapy response. In this review, we provide a comprehensive list of potentially functional miRNA-related SNPs and summarize their importance as candidate cancer biomarkers. MicroRNAs (miRNAs) are small non-coding RNAs, which regulate gene expression. Single nucleotide polymorphisms (SNPs) may occur in miRNA biogenesis pathway genes, primary miRNA, pre-miRNA or a mature miRNA sequence. Such polymorphisms may be functional with respect to biogenesis and actions of mature miRNA. Specific SNPs were identified in predicted miRNA target sites within 3' untranslated regions of mRNAs. These SNPs have a potential to affect the efficiency of miRNA binding to the target sites or can create or disrupt binding sites. Resulting gene dysregulation may involve changes in phenotype and may eventually prove critical for the susceptibility to cancer and its onset as well as for estimates of prognosis and therapy response. In this review, we provide a comprehensive list of potentially functional miRNA-related SNPs and summarize their importance as candidate cancer biomarkers. (en)
Title	Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer (en)
skos:prefLabel	Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer (en)
skos:notation	RIV/00209805:_____/12:#0000339!RIV13-MZ0-00209805
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(NS10352), P(NS9814), Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Vyzula, Rostislav Svoboda, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	137914
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/12:#0000339
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microRNA; polymorphism; SNP; cancer; risk factor; diagnosis; prognosis; prediction (en)
http://linked.open.../riv/klicoveSlovo	SNP cancer diagnosis polymorphism prediction prognosis risk factor microRNA
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A49352D2C377]
http://linked.open...i/riv/nazevZdroje	Journal of cellular and molecular medicine
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	MicroRNAs significance in chemoprotective effects of phytochemicals contained in Brassica vegetables and association of their binding sites polymorphisms with risk of colorectal cancer Identification and functional studies of microRNAs with predictive and prognostic significance in patients with colorectal cancer
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Slabý, Ondřej Svoboda, Marek Vyzula, Rostislav
http://linked.open...ain/vavai/riv/wos	000298586600002
http://linked.open...n/vavai/riv/zamer	Functional diagnostics of malignant tumours
issn	1582-1838
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1582-4934.2011.01359.x

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