About: Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer

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About: Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.wjgnet.com/1007-9327/full/v18/i22/2827.htm
Description	AIM: To investigate whether selected single nucleotide polymorphisms (SNPs) in miR-196a2, miR-27a and miR-146a genes are associated with sporadic colorectal cancer (CRC). METHODS: In order to investigate the effect of these SNPs in CRC, we performed a case-control study of 197 cases of sporadic CRC and 212 cancer-free controls originating from the Central-European Caucasian population using TaqMan Real-Time polymerase chain reaction and allelic discrimination analysis. RESULTS: The genotype and allele frequencies of SNPs were compared between the cases and the controls. None of the performed analysis showed any statistically significant results. CONCLUSION: Our data suggest a lack of association between rs11614913, rs895819 and rs2910164 and colorectal cancer risk in the Central-European Caucasian population, a population with an extremely high incidence of sporadic colorectal cancer. AIM: To investigate whether selected single nucleotide polymorphisms (SNPs) in miR-196a2, miR-27a and miR-146a genes are associated with sporadic colorectal cancer (CRC). METHODS: In order to investigate the effect of these SNPs in CRC, we performed a case-control study of 197 cases of sporadic CRC and 212 cancer-free controls originating from the Central-European Caucasian population using TaqMan Real-Time polymerase chain reaction and allelic discrimination analysis. RESULTS: The genotype and allele frequencies of SNPs were compared between the cases and the controls. None of the performed analysis showed any statistically significant results. CONCLUSION: Our data suggest a lack of association between rs11614913, rs895819 and rs2910164 and colorectal cancer risk in the Central-European Caucasian population, a population with an extremely high incidence of sporadic colorectal cancer. (en)
Title	Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer (en)
skos:prefLabel	Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer (en)
skos:notation	RIV/00209805:_____/12:#0000336!RIV13-MSM-00209805
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(LM2010004), P(NS10352), P(NS9814), Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	22
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Rédová, Martina Šachlová, Milana Kiss, Igor Vyzula, Rostislav Svoboda, Marek Héžová, Renata
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	135180
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/12:#0000336
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	association study; colorectal cancer; microRNA; single nucleotide polymorphism (en)
http://linked.open.../riv/klicoveSlovo	association study single nucleotide polymorphism colorectal cancer microRNA
http://linked.open...odStatuVydavatele	CN - Čínská lidová republika
http://linked.open...ontrolniKodProRIV	[FFFB0FA10E94]
http://linked.open...i/riv/nazevZdroje	World journal of gastroenterology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	BBMRI_CZ in the building of the Czech part of a large distributed research infrastructure of pan-European importance: the creation and operation of the network of banks of biological material for biomedical research Central european institute of technology MicroRNAs significance in chemoprotective effects of phytochemicals contained in Brassica vegetables and association of their binding sites polymorphisms with risk of colorectal cancer Identification and functional studies of microRNAs with predictive and prognostic significance in patients with colorectal cancer
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Kiss, Igor Rédová, Martina Slabý, Ondřej Šachlová, Milana Svoboda, Marek Vyzula, Rostislav Héžová, Renata
http://linked.open...ain/vavai/riv/wos	000305445200012
http://linked.open...n/vavai/riv/zamer	Functional diagnostics of malignant tumours
issn	1007-9327
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.3748/wjg.v18.i22.2827

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