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Description
  • The TP53 gene has a major role as an intgerator of cellular stresses and is commnly mutated or inactivated in human cancers. As well as inducing growth arrest and cell death by transcriptional activation of target genes after genotoxic stress, p53 also responds to hypoxia. Under hypoxic conditions, p53 acts largely as a transcriptional repressor but also enhancer HUF-1-mediated activation of apoptosis. Mutation to TP53 in tumours allows increased survival in hypoxia, suggesting that these pathways could be therapeutically useful. The two other members of the p53-family, p63 and p73, also influence hypoxic responses in poorly defined ways.
  • The TP53 gene has a major role as an intgerator of cellular stresses and is commnly mutated or inactivated in human cancers. As well as inducing growth arrest and cell death by transcriptional activation of target genes after genotoxic stress, p53 also responds to hypoxia. Under hypoxic conditions, p53 acts largely as a transcriptional repressor but also enhancer HUF-1-mediated activation of apoptosis. Mutation to TP53 in tumours allows increased survival in hypoxia, suggesting that these pathways could be therapeutically useful. The two other members of the p53-family, p63 and p73, also influence hypoxic responses in poorly defined ways. (en)
Title
  • Hypoxia and p53
  • Hypoxia and p53 (en)
skos:prefLabel
  • Hypoxia and p53
  • Hypoxia and p53 (en)
skos:notation
  • RIV/00209805:_____/12:#0000331!RIV13-MSM-00209805
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(ED2.1.00/03.0101), P(NT13794), Z(MZ0MOU2005)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 140146
http://linked.open...ai/riv/idVysledku
  • RIV/00209805:_____/12:#0000331
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • hypoxia; p53 protein family; TP53 gene; HIF; apoptosis; angiogenesis; chaperone (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [C30169D61901]
http://linked.open...i/riv/mistoVydani
  • Frankfurt am Main
http://linked.open...i/riv/nazevZdroje
  • Tumour hypoxia: molecular mechanism and clinical implications
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...v/pocetStranKnihy
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Hrstka, Roman
  • Vojtěšek, Bořivoj
  • Müller, Petr
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Peter Lang
https://schema.org/isbn
  • 978-3-631-63991-7
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