About: The role of p63 in cancer, stem cells and cancer stem cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.springerlink.com/content/9801w775x3587419/?MUD=MP
Description	The transcription factor p63 has important functions in tumorigenesis, epidermal differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms that have different or even antagonistic roles in these processes. The balance of p63 isoforms, together with the presence or absence of the other p53 family members, p73 and p53, has a striking biological impact. There is increasing evidence that interactions between p53-family members, whether cooperative or antagonistic, are involved in various cell processes. This review summarizes the current understanding of the role of p63 in tumorigenesis, metastasis, cell migration and senescence. In particular, recent data indicate important roles in adult stem cell and cancer stem cell regulation and in the response of cancer cells to therapy. The transcription factor p63 has important functions in tumorigenesis, epidermal differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms that have different or even antagonistic roles in these processes. The balance of p63 isoforms, together with the presence or absence of the other p53 family members, p73 and p53, has a striking biological impact. There is increasing evidence that interactions between p53-family members, whether cooperative or antagonistic, are involved in various cell processes. This review summarizes the current understanding of the role of p63 in tumorigenesis, metastasis, cell migration and senescence. In particular, recent data indicate important roles in adult stem cell and cancer stem cell regulation and in the response of cancer cells to therapy. (en)
Title	The role of p63 in cancer, stem cells and cancer stem cells The role of p63 in cancer, stem cells and cancer stem cells (en)
skos:prefLabel	The role of p63 in cancer, stem cells and cancer stem cells The role of p63 in cancer, stem cells and cancer stem cells (en)
skos:notation	RIV/00209805:_____/11:#0000147!RIV12-MSM-00209805
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0101), P(GPP301/10/P431), Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vojtěšek, Bořivoj Nekulová, Marta Holčáková, Jitka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	227496
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/11:#0000147
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	p63; TAp63; ΔNp63; p53 family; cancer; stem cells (en)
http://linked.open.../riv/klicoveSlovo	stem cells p63 ΔNp63 TAp63 p53 family cancer
http://linked.open...odStatuVydavatele	PL - Polská republika
http://linked.open...ontrolniKodProRIV	[2D50F80FEF34]
http://linked.open...i/riv/nazevZdroje	Cellular and molecular biology letters
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of p63 expression in human epithelial cells Regional Centre for Applied Molecular Oncology (RECAMO)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Vojtěšek, Bořivoj Holčáková, Jitka Nekulová, Marta
http://linked.open...ain/vavai/riv/wos	000288798300008
http://linked.open...n/vavai/riv/zamer	Functional diagnostics of malignant tumours
issn	1425-8153
number of pages	32 (xsd:int)
http://bibframe.org/vocab/doi	10.2478/s11658-011-0009-9

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