About: Anterior gradient 2: a novel player in tumor cell biology

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About: Anterior gradient 2: a novel player in tumor cell biology Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0304383511000152
Description	AGR2 has evolutionarily conserved roles in development and tissue regeneration and is linked with several human cancers. The exact functions and regulation of AGR2 are poorly understood, but current data identify AGR2 as a clinically relevant factor that modulates the behavior and response of hormone-dependent cancers (breast, prostate) and hormone-independent cancers (colorectal, pancreatic, esophageal and other common cancers). AGR2 protein expression induces metastasis, acts as a p53 tumor suppressor inhibitor and survival factor, participates directly in neoplastic transformation and is involved in drug resistance. Thus, AGR2 is an important tumor biomarker and negative prognostic factor potentially exploitable in clinical practice. AGR2 has evolutionarily conserved roles in development and tissue regeneration and is linked with several human cancers. The exact functions and regulation of AGR2 are poorly understood, but current data identify AGR2 as a clinically relevant factor that modulates the behavior and response of hormone-dependent cancers (breast, prostate) and hormone-independent cancers (colorectal, pancreatic, esophageal and other common cancers). AGR2 protein expression induces metastasis, acts as a p53 tumor suppressor inhibitor and survival factor, participates directly in neoplastic transformation and is involved in drug resistance. Thus, AGR2 is an important tumor biomarker and negative prognostic factor potentially exploitable in clinical practice. (en)
Title	Anterior gradient 2: a novel player in tumor cell biology Anterior gradient 2: a novel player in tumor cell biology (en)
skos:prefLabel	Anterior gradient 2: a novel player in tumor cell biology Anterior gradient 2: a novel player in tumor cell biology (en)
skos:notation	RIV/00209805:_____/11:#0000146!RIV12-MSM-00209805
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0101), P(GAP301/10/1615), P(LC06035), Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hrstka, Roman Brychtová, Veronika Vojtěšek, Bořivoj
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	186380
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/11:#0000146
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	AGR2; tumor metastasis; breast cancer; pancreatic cancer; Barrett esophagus (en)
http://linked.open.../riv/klicoveSlovo	AGR2 Barrett esophagus pancreatic cancer tumor metastasis breast cancer
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[77BFD566F91F]
http://linked.open...i/riv/nazevZdroje	Cancer letters
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Rodina proteinů AGR2: úloha v biologii nádorové buňky Regional Centre for Applied Molecular Oncology (RECAMO) Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	304
http://linked.open...iv/tvurceVysledku	Brychtová, Veronika Hrstka, Roman Vojtěšek, Bořivoj
http://linked.open...ain/vavai/riv/wos	000289383400001
http://linked.open...n/vavai/riv/zamer	Functional diagnostics of malignant tumours
issn	0304-3835
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.canlet.2010.12.023

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