About: Loss of the p53 tumor suppressor aktivity is associated with negative prognosis of mantle cell lymphoma

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About: Loss of the p53 tumor suppressor aktivity is associated with negative prognosis of mantle cell lymphoma Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.spandidos-publications.com/ijo/36/3/699
Description	Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also necessary for progression of the disease. We analyzed the p53 tumor suppressor in tumor tissue of 33 patients with MCL. The p53 status was determined by functional analyses in yeast (FASAY) and by cDNA sequencing. The level of the p53 protein was assessed by immunohistochemistry and immunoblotting. Loss of the p53-specific locus 17p13.3 was detected by FISH. Mutations in the p53 gene were detected in nine samples and they included eight missense mutations and one short deletion causing frame shift and premature stop codon formation in position 169. This mutation was associated with mRNA decay as revealed by sequencing of the p53 gDNA. All eight missense mutations were manifested by accumulation of the p53 protein in nuclei of tumor cells and three of them exhibited loss of the p53-specific locus 17p13.3. The p53 mutations were shown to be a negative prognostic marker in MCL. Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also necessary for progression of the disease. We analyzed the p53 tumor suppressor in tumor tissue of 33 patients with MCL. The p53 status was determined by functional analyses in yeast (FASAY) and by cDNA sequencing. The level of the p53 protein was assessed by immunohistochemistry and immunoblotting. Loss of the p53-specific locus 17p13.3 was detected by FISH. Mutations in the p53 gene were detected in nine samples and they included eight missense mutations and one short deletion causing frame shift and premature stop codon formation in position 169. This mutation was associated with mRNA decay as revealed by sequencing of the p53 gDNA. All eight missense mutations were manifested by accumulation of the p53 protein in nuclei of tumor cells and three of them exhibited loss of the p53-specific locus 17p13.3. The p53 mutations were shown to be a negative prognostic marker in MCL. (en)
Title	Loss of the p53 tumor suppressor aktivity is associated with negative prognosis of mantle cell lymphoma Loss of the p53 tumor suppressor aktivity is associated with negative prognosis of mantle cell lymphoma (en)
skos:prefLabel	Loss of the p53 tumor suppressor aktivity is associated with negative prognosis of mantle cell lymphoma Loss of the p53 tumor suppressor aktivity is associated with negative prognosis of mantle cell lymphoma (en)
skos:notation	RIV/00209805:_____/10:#0000275!RIV12-MZ0-00209805
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(NR9305), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Fabian, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	268934
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/10:#0000275
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mantle cell lymphoma; tumor suppressor p53; FASAY; overall survival; RNA decay (en)
http://linked.open.../riv/klicoveSlovo	overall survival FASAY mantle cell lymphoma tumor suppressor p53 RNA decay
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[B55288CFF321]
http://linked.open...i/riv/nazevZdroje	International journal of oncology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Complex analysis of p53 tumor suppressor in non-Hodgkin´s lymphomas
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	36
http://linked.open...iv/tvurceVysledku	Šmardová, Jana Fabian, Pavel
http://linked.open...ain/vavai/riv/wos	000274718400020
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	1019-6439
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.3892/ijo_00000545

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