About: Vitamin D pathway genes, diet, and risk of renal cell carcinoma

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.hindawi.com/journals/ije/2010/879362/
Description	Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR). Variation in both genes has been shown to modify renal cell carcinoma (RCC) risk. Therefore, we investigated whether VDR and RXRA polymorphisms modify associations between RCC risk and frequency of dietary intake of vitamin D and calcium rich foods, and occupational ultraviolet exposure among 777 RCC case and 1035 controls from Central and Eastern Europe. A positive association was observed in this population between increasing dietary intake frequency of yogurt, while an inverse association was observed with egg intake frequency. Results suggest that variants in the RXRA gene modified the associations observed between RCC risk and calcium and vitamin D intake. Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR). Variation in both genes has been shown to modify renal cell carcinoma (RCC) risk. Therefore, we investigated whether VDR and RXRA polymorphisms modify associations between RCC risk and frequency of dietary intake of vitamin D and calcium rich foods, and occupational ultraviolet exposure among 777 RCC case and 1035 controls from Central and Eastern Europe. A positive association was observed in this population between increasing dietary intake frequency of yogurt, while an inverse association was observed with egg intake frequency. Results suggest that variants in the RXRA gene modified the associations observed between RCC risk and calcium and vitamin D intake. (en)
Title	Vitamin D pathway genes, diet, and risk of renal cell carcinoma Vitamin D pathway genes, diet, and risk of renal cell carcinoma (en)
skos:prefLabel	Vitamin D pathway genes, diet, and risk of renal cell carcinoma Vitamin D pathway genes, diet, and risk of renal cell carcinoma (en)
skos:notation	RIV/00209805:_____/10:#0000265!RIV12-MZ0-00209805
http://linked.open...avai/riv/aktivita	I P S V
http://linked.open...avai/riv/aktivity	I, P(NS10290), S, V
http://linked.open...iv/cisloPeriodika	2010
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Navrátilová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	295833
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/10:#0000265
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	renal cell carcinoma; diet; genes; vitamin D (en)
http://linked.open.../riv/klicoveSlovo	genes diet - livestock depredation - predator - prey density - scat analysis renal cell carcinoma vitamin D - vitamin D receptor - sarcopenia - cardiac failure - dementia - depression
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[46F6554953ED]
http://linked.open...i/riv/nazevZdroje	International journal of endocrinology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	17 (xsd:int)
http://linked.open...vavai/riv/projekt	Epidemiologic study of genetic and behavioral risk factors in kidney cancer
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Navrátilová, Marie Karami, Sara
issn	1687-8337
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1155/2010/879362

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