About: Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases

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About: Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cisplatin and doxorubicin are widely used anticancer drugs that cause DNA damage, which activates the ATM-Chk2-p53 pathway in cancer cells. This activation leads to cell cycle block or apoptosis, depending on the nature of the DNA damage. In an attempt to enhance the effects of these agents, we inhibited ATM/ATR and Chk2, which are known upstream regulators of p53. The cancor cell lines A2780 and ARN8, bearing the wild-type p53 protein, were used to study changes in p53 activation and trans-activation. Our results suggest that the G1-checkpoint, normally activated by DNA damage, is functionally overcome by the action of kinase inhibitors that sensitize cells to apoptosis. Both inhibitors show these effects, albeit with variable intensity in different cell lines, which is promising for other studies and theoretically for use in clinical practice. Cisplatin and doxorubicin are widely used anticancer drugs that cause DNA damage, which activates the ATM-Chk2-p53 pathway in cancer cells. This activation leads to cell cycle block or apoptosis, depending on the nature of the DNA damage. In an attempt to enhance the effects of these agents, we inhibited ATM/ATR and Chk2, which are known upstream regulators of p53. The cancor cell lines A2780 and ARN8, bearing the wild-type p53 protein, were used to study changes in p53 activation and trans-activation. Our results suggest that the G1-checkpoint, normally activated by DNA damage, is functionally overcome by the action of kinase inhibitors that sensitize cells to apoptosis. Both inhibitors show these effects, albeit with variable intensity in different cell lines, which is promising for other studies and theoretically for use in clinical practice. (en)
Title	Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases (en)
skos:prefLabel	Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases (en)
skos:notation	RIV/00209805:_____/10:#0000118!RIV11-GA0-00209805
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/08/1468), P(GAP301/10/1615), P(NS9812), Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hrstka, Roman Vojtěšek, Bořivoj Holčáková, Jitka Bouchalová, Pavla Greplová, Kristína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	291342
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/10:#0000118
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	protein p53, ATM/ATR kinases, Chk2, Inhibitors of DNA-damage activated kinases, Doxorubicin, Cisplatin (en)
http://linked.open.../riv/klicoveSlovo	ATM/ATR kinases Chk2 Inhibitors of DNA-damage activated kinases Cisplatin Doxorubicin protein p53
http://linked.open...odStatuVydavatele	PL - Polská republika
http://linked.open...ontrolniKodProRIV	[AEF0DA2EEDAF]
http://linked.open...i/riv/nazevZdroje	Cellular and molecular biology letters
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Rodina proteinů AGR2: úloha v biologii nádorové buňky Molecular and cellular consequences of p53 manipulation using heat shock protein inhibitors and E3-ligases. Elucidating the role of ubiquitin-chaperone degradation machinery in cancer and modulating its biochemical functions using targeted chaperone inhibitors
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Hrstka, Roman Vojtěšek, Bořivoj Holčáková, Jitka Greplová, Kristýna Hublarová, Pavla
http://linked.open...ain/vavai/riv/wos	000278930100008
http://linked.open...n/vavai/riv/zamer	Functional diagnostics of malignant tumours
issn	1425-8153
number of pages	12 (xsd:int)

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