About: DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation

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About: DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	ΔNp63α is an epithelial progenitor cell marker that maintains epidermal stem cell self-renewal capacity. We now report that phosphorylation of the p53 tumour suppressor is positively regulated by ΔNp63α in immortalised human keratinocytes. ΔNp63α depletion by RNAi reduces steady-state ATM mRNA and protein levels, and attenuates p53 Serine-15 phosphorylation. Conversely, ectopic expression of ΔNp63α in p63-null tumour cells stimulates ATM transcription and p53 Serine-15 phosphorylation. We show that ATM is a direct ΔNp63α transcriptional target and that the ΔNp63α response element localizes to the ATM promoter CCAAT sequence. Germline p63 point mutations are associated with a range of ectodermal developmental disorders, and targeted p63 deletion in the skin causes premature ageing. The ΔNp63α-ATM-p53 damage-response pathway may therefore function in epithelial development, carcinogenesis and the ageing processes. ΔNp63α is an epithelial progenitor cell marker that maintains epidermal stem cell self-renewal capacity. We now report that phosphorylation of the p53 tumour suppressor is positively regulated by ΔNp63α in immortalised human keratinocytes. ΔNp63α depletion by RNAi reduces steady-state ATM mRNA and protein levels, and attenuates p53 Serine-15 phosphorylation. Conversely, ectopic expression of ΔNp63α in p63-null tumour cells stimulates ATM transcription and p53 Serine-15 phosphorylation. We show that ATM is a direct ΔNp63α transcriptional target and that the ΔNp63α response element localizes to the ATM promoter CCAAT sequence. Germline p63 point mutations are associated with a range of ectodermal developmental disorders, and targeted p63 deletion in the skin causes premature ageing. The ΔNp63α-ATM-p53 damage-response pathway may therefore function in epithelial development, carcinogenesis and the ageing processes. (en)
Title	DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation (en)
skos:prefLabel	DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation (en)
skos:notation	RIV/00209805:_____/10:#0000112!RIV11-GA0-00209805
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GPP301/10/P431), P(NS9812), Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hrstka, Roman Vojtěšek, Bořivoj Nekulová, Marta Holčáková, Jitka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	253233
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/10:#0000112
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ΔNp63α, ATM, p53 (en)
http://linked.open.../riv/klicoveSlovo	p53 ATM ΔNp63α
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[074E4BA19D01]
http://linked.open...i/riv/nazevZdroje	Molecular cancer
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of p63 expression in human epithelial cells Elucidating the role of ubiquitin-chaperone degradation machinery in cancer and modulating its biochemical functions using targeted chaperone inhibitors
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Hrstka, Roman Vojtěšek, Bořivoj Holčáková, Jitka Nekulová, Miroslava
http://linked.open...ain/vavai/riv/wos	000282458400001
http://linked.open...n/vavai/riv/zamer	Functional diagnostics of malignant tumours
issn	1476-4598
number of pages	13 (xsd:int)

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