About: Stress-dependent changes in the properties of p53 complexes by the alternative translation product p53/47     Goto   Sponge   NotDistinct   Permalink

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Description
  • Hodnotili jsme vliv p53/47 na p53 závislou aktivaci genů. Komplexy p53/47-p53 hetero-oligomerů se vyznačují odlišnou odpovědí na přítomnost DNA poškozujících látek než homo-oligomery. p53/47 tedy hraje důležitou roli v regulaci aktivity p53 v odpovědi buňky na stresové podmínky. (cs)
  • We have investigated the influence of p53/47 on p53-dependent gene activation and modifications. p53/47-p53 hetero-oligomers complexes respond different to DNA-damaging drugs compared to homo-oligomers. p53/47 expression is cell stress-dependent. This indicates the importance of p53/47 regulating p53 activity in response to cell damage and stress.
  • We have investigated the influence of p53/47 on p53-dependent gene activation and modifications. p53/47-p53 hetero-oligomers complexes respond different to DNA-damaging drugs compared to homo-oligomers. p53/47 expression is cell stress-dependent. This indicates the importance of p53/47 regulating p53 activity in response to cell damage and stress. (en)
Title
  • Stress-dependent changes in the properties of p53 complexes by the alternative translation product p53/47
  • Stress-dependent changes in the properties of p53 complexes by the alternative translation product p53/47 (en)
  • Na stresu závislé změny vlastností komplexů p53 vlivem p53/47, produktu alternativní translace (cs)
skos:prefLabel
  • Stress-dependent changes in the properties of p53 complexes by the alternative translation product p53/47
  • Stress-dependent changes in the properties of p53 complexes by the alternative translation product p53/47 (en)
  • Na stresu závislé změny vlastností komplexů p53 vlivem p53/47, produktu alternativní translace (cs)
skos:notation
  • RIV/00209805:_____/08:#0000083!RIV09-MZ0-00209805
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA301/05/0416), P(NR8338)
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 397700
http://linked.open...ai/riv/idVysledku
  • RIV/00209805:_____/08:#0000083
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • p53; p53/47; cancer; translation; transcription factor; transactivation; gene expression; oligomerisation; apoptosis; deltaNp53 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [B44E70FB5192]
http://linked.open...i/riv/nazevZdroje
  • Cell cycle
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 7
http://linked.open...iv/tvurceVysledku
  • Hrstka, Roman
  • Vojtěšek, Bořivoj
http://linked.open...ain/vavai/riv/wos
  • 000255219500019
issn
  • 1538-4101
number of pages
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