| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - To clarify the stabilization of p53 mutants in tumours, we analysed factors that affect their folding and degradation. The demonstration of a complex interplay between Hsp90, Hsp70 and CHIP that regulate the stability of different p53 mutant proteins improves our understanding of the pro-tumorigenic effects of increased Hsp90 activity during multi-stage carcinogenesis.
- To clarify the stabilization of p53 mutants in tumours, we analysed factors that affect their folding and degradation. The demonstration of a complex interplay between Hsp90, Hsp70 and CHIP that regulate the stability of different p53 mutant proteins improves our understanding of the pro-tumorigenic effects of increased Hsp90 activity during multi-stage carcinogenesis. (en)
- Abychom objasnili stabilizace mutantních p53 v nádorech, studovali jsme faktory, které jsou zodpovědné za jejich sbalování a degradaci. Důkaz komplexní spolupráce mezi proteiny Hsp90, Hsp70 a CHIP, které regulují stabilitu odlišných forem p53 mutantů nám umožnilo pochopit pronádorový účinek zvýšené aktivity Hsp90 během procesu kancerogeneze. (cs)
|
| Title
| - Chaperone dependent stabilization and degradation of p53 mutants
- Chaperone dependent stabilization and degradation of p53 mutants (en)
- Na chaperonech závislá stabilizace a degradace mutantních p53 (cs)
|
| skos:prefLabel
| - Chaperone dependent stabilization and degradation of p53 mutants
- Chaperone dependent stabilization and degradation of p53 mutants (en)
- Na chaperonech závislá stabilizace a degradace mutantních p53 (cs)
|
| skos:notation
| - RIV/00209805:_____/08:#0000079!RIV09-MZ0-00209805
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA301/05/0416), P(LC06035), P(NR8338)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00209805:_____/08:#0000079
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - chaperones; p53 mutant; stabilization; degradation; CHIP (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Hrstka, Roman
- Vojtěšek, Bořivoj
- Müller, Petr
|
| http://linked.open...ain/vavai/riv/wos
| |
| issn
| |
| number of pages
| |
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