About: Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Poruchy metabolismu homocyteinu jsou v medicíně známy desítky let, jako vrozené choroby. Tato skupina chorob zahrnuje klasickou cystinurii i další transsulfurační poruchy, kde se jedná vždy o demethylaci a uvolnění redukovaného tetrahydrofolátu. Antifoláty jsou cytostatika atakující různé kroky folátového metabolismu a ovlivňují metabolismus homocysteinu v buňce i plasmě. To se projeví také u terapie methotrexatem a tato role je nyní aktuálně studována . V klinické praxi jsou studovány genetické poruchy metabolismu folátů a homocysteinu z hlediska farmakologie i famakogenetiky. Práce navrhuje možné cesty užití homocysteinu jako biomarkeru antifolátové terapie. (cs) For decades it has been well known that elevated levels of homocysteine are harmful to humans on the basis of clinical observations derived from classical model diseases, such as inherited metabolic disorders. This group of diseases includes classical homocystinuria and several other inherited diseases affecting the so-called 'transsulfuration pathways'. Homocysteine lies in a metabolic checkpoint that interconnects one-carbon-transferring reactions with metabolism of sulfur-containing amino acids, since every molecule of 5-methyltetrahydrofolate derived either from plasma or generated from other folate species must be demethylated to liberate the reduced tetrahydrofolate. This unidirectional mechanism operates in every cell and has no alternative in eukaryotic cells. Antifolates are a group of anticancer agents targeting various metabolic steps within folate metabolism. They exert an indirect influence on the rate of appearance/disappearance of homocysteine from cellular and plasma compartments. Rece For decades it has been well known that elevated levels of homocysteine are harmful to humans on the basis of clinical observations derived from classical model diseases, such as inherited metabolic disorders. This group of diseases includes classical homocystinuria and several other inherited diseases affecting the so-called 'transsulfuration pathways'. Homocysteine lies in a metabolic checkpoint that interconnects one-carbon-transferring reactions with metabolism of sulfur-containing amino acids, since every molecule of 5-methyltetrahydrofolate derived either from plasma or generated from other folate species must be demethylated to liberate the reduced tetrahydrofolate. This unidirectional mechanism operates in every cell and has no alternative in eukaryotic cells. Antifolates are a group of anticancer agents targeting various metabolic steps within folate metabolism. They exert an indirect influence on the rate of appearance/disappearance of homocysteine from cellular and plasma compartments. Rece (en)
Title	Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy (en) Homocystein: využití jako farmakodynamický biomarker antifolátové chemoterapie (cs)
skos:prefLabel	Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy (en) Homocystein: využití jako farmakodynamický biomarker antifolátové chemoterapie (cs)
skos:notation	RIV/00209805:_____/04:00013645!RIV/2005/MZ0/L26005/N
http://linked.open.../vavai/riv/strany	1151; 1162
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NC7104)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Valík, Dalibor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	566621
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/04:00013645
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Antimetabolites, antineoplastic;biological markers;folic acid antagonists;homocysteine;methotrexate (en)
http://linked.open.../riv/klicoveSlovo	antineoplastic folic acid antagonists homocysteine Antimetabolites biological markers methotrexate
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[36E12B7CF8C1]
http://linked.open...i/riv/nazevZdroje	Pharmacogenomics
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Plasma homocysteine and functional activation of p53 as putative markers of effect of high-dose methotrexate in lymphoblastic malignancies in children
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Valík, Dalibor
issn	1462-2416
number of pages	12 (xsd:int)

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 9 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software