About: Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells

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About: Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The p53 tumor suppressor protein is known to regulate the expression of the CD95 (Fas/APO-1) death receptor in a small subset of normal cell types as well as in many cancer cell types. However, whether p53-dependent regulation of CD95 expression is consistently associated with increased susceptibility to CD95-mediated cell death is poorly understood. To address this issue, we examined constitutive and induced CD95 surface expression and function in wild-type p53-expressing carcinoma cells relative to their isogenic p53-inactivated counterparts. We compared HCT116 colorectal carcinoma cells with their p53 biallelic knock-outs and control-transfected MCF-7 breast carcinoma cells with MCF-7 cells expressing a miniprotein inhibitor of p53 (p53DD). In both cell lines, the constitutive expression of surface CD95 was significantly reduced in p53-inactivated cells, as was the apoptotic response to agonistic anti-CD95 antibody. In both cell lines, only cells with wild-type p53 activity exhibited up-regulation. The p53 tumor suppressor protein is known to regulate the expression of the CD95 (Fas/APO-1) death receptor in a small subset of normal cell types as well as in many cancer cell types. However, whether p53-dependent regulation of CD95 expression is consistently associated with increased susceptibility to CD95-mediated cell death is poorly understood. To address this issue, we examined constitutive and induced CD95 surface expression and function in wild-type p53-expressing carcinoma cells relative to their isogenic p53-inactivated counterparts. We compared HCT116 colorectal carcinoma cells with their p53 biallelic knock-outs and control-transfected MCF-7 breast carcinoma cells with MCF-7 cells expressing a miniprotein inhibitor of p53 (p53DD). In both cell lines, the constitutive expression of surface CD95 was significantly reduced in p53-inactivated cells, as was the apoptotic response to agonistic anti-CD95 antibody. In both cell lines, only cells with wild-type p53 activity exhibited up-regulation. (en)
Title	Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells (en)
skos:prefLabel	Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells (en)
skos:notation	RIV/00209805:_____/03:00008092!RIV/2004/GA0/L26004/N
http://linked.open.../vavai/riv/strany	7176; 7184
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA301/03/0545), P(NC6402), P(NC7131), P(NC7133)
http://linked.open...iv/cisloPeriodika	21
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Sheard, Michael Allen Vojtěšek, Bořivoj
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	625912
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/03:00008092
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antigens, CD95/biosynthesis;apoptosis/physiology;breast neoplasms/genetics;cell line, tumor;protein p53/antagonists & in;ibitors; up;regulation/physiology (en)
http://linked.open.../riv/klicoveSlovo	tumor antigens cell line CD95/biosynthesis apoptosis/physiology breast neoplasms/genetics ibitors protein p53/antagonists & in regulation/physiology up
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DE356E1D3629]
http://linked.open...i/riv/nazevZdroje	Cancer Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of functional alterations of mutant forms of p53 protein in human cancers. Delineation of molecular mechanisms enhancing death-receptor mediated apoptosis in tumor cells Combined treatment of tumor cells with chemotherapeutics and cytokines may optimize Fas-mediated apoptosis. Characterizing the role of p53-mediated enhancement of TRAIL-R2 and CD95 expression in the induction of apoptosis by TRAIL and CD178
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	63
http://linked.open...iv/tvurceVysledku	Vojtěšek, Bořivoj Sheard, Michael Allen
issn	0008-5472
number of pages	9 (xsd:int)

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