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Description
| - HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.
- HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics. (en)
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Title
| - HPLC Analysis in Drug Level Monitoring of K027
- HPLC Analysis in Drug Level Monitoring of K027 (en)
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skos:prefLabel
| - HPLC Analysis in Drug Level Monitoring of K027
- HPLC Analysis in Drug Level Monitoring of K027 (en)
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skos:notation
| - RIV/00179906:_____/13:10172651!RIV14-MZ0-00179906
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00179906:_____/13:10172651
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - quantitation; reversed-phase separation; blood-brain barrier; pharmacokinetics; K027; HPLC (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kuča, Kamil
- Adem, A.
- Hasan, M. Y. B.
- Hashemi, F.
- Kalasz, H.
- Nurulain, S. M.
- Szegi, P.
- Tekes, K.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1556/AChrom.25.2013.4.8
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