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Description
  • HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.
  • HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics. (en)
Title
  • HPLC Analysis in Drug Level Monitoring of K027
  • HPLC Analysis in Drug Level Monitoring of K027 (en)
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  • HPLC Analysis in Drug Level Monitoring of K027
  • HPLC Analysis in Drug Level Monitoring of K027 (en)
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  • RIV/00179906:_____/13:10172651!RIV14-MZ0-00179906
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  • 78187
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  • RIV/00179906:_____/13:10172651
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  • quantitation; reversed-phase separation; blood-brain barrier; pharmacokinetics; K027; HPLC (en)
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  • PL - Polská republika
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  • Acta Chromatographica
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  • 25
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  • Kuča, Kamil
  • Adem, A.
  • Hasan, M. Y. B.
  • Hashemi, F.
  • Kalasz, H.
  • Nurulain, S. M.
  • Szegi, P.
  • Tekes, K.
http://linked.open...ain/vavai/riv/wos
  • 000325291400008
issn
  • 1233-2356
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  • 10.1556/AChrom.25.2013.4.8
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