About: Percutaneous toxicity and decontamination of soman, VX, and paraoxon in rats using detegrents

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.degruyter.com/view/j/aiht.2013.64.issue-2/10004-1254-64-2013-2290/10004-1254-64-2013-2290.xml
Description	Highly toxic organophosphorus compounds (OPs) were originally developed for warfare or as agricultural pesticides. Today, OPs represent a serious threat to military personnel and civilians. This study investigates the in vivo decontamination of male Wistar rats percutaneously exposed to paraoxon and two potent nerve agents - soman (GD) and VX. Four commercial detergents were tested as decontaminants -Neodekont (TM), Argos (TM) Dermogel (TM), and FloraFree (TM). Decontamination performed 2 min after exposure resulted in a higher survival rate in comparison with non-decontaminated controls. The decontamination effectiveness was expressed as protective ratio (PR, median lethal dose of agent in decontaminated animals divided by the median lethal dose of agent in untreated animals). The highest decontamination effectiveness was consistently achieved with Argos (TM) (PR=2.3 to 64.8), followed by Dermogel (TM) (PR=2.4 to 46.1). Neodekont (TM) and FloraFree (TM) provided the lowest decontamination effectiveness, equivalent to distilled water (PR=1.0 to 43.2). Highly toxic organophosphorus compounds (OPs) were originally developed for warfare or as agricultural pesticides. Today, OPs represent a serious threat to military personnel and civilians. This study investigates the in vivo decontamination of male Wistar rats percutaneously exposed to paraoxon and two potent nerve agents - soman (GD) and VX. Four commercial detergents were tested as decontaminants -Neodekont (TM), Argos (TM) Dermogel (TM), and FloraFree (TM). Decontamination performed 2 min after exposure resulted in a higher survival rate in comparison with non-decontaminated controls. The decontamination effectiveness was expressed as protective ratio (PR, median lethal dose of agent in decontaminated animals divided by the median lethal dose of agent in untreated animals). The highest decontamination effectiveness was consistently achieved with Argos (TM) (PR=2.3 to 64.8), followed by Dermogel (TM) (PR=2.4 to 46.1). Neodekont (TM) and FloraFree (TM) provided the lowest decontamination effectiveness, equivalent to distilled water (PR=1.0 to 43.2). (en)
Title	Percutaneous toxicity and decontamination of soman, VX, and paraoxon in rats using detegrents Percutaneous toxicity and decontamination of soman, VX, and paraoxon in rats using detegrents (en)
skos:prefLabel	Percutaneous toxicity and decontamination of soman, VX, and paraoxon in rats using detegrents Percutaneous toxicity and decontamination of soman, VX, and paraoxon in rats using detegrents (en)
skos:notation	RIV/00179906:_____/13:10159528!RIV14-MZ0-00179906
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kuča, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	95729
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/13:10159528
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	vivo; model; efficacy; protection; reactivators; domestic swine; organophosphorus compounds; in-vitro; skin decontamination; chemical warfare agents (en)
http://linked.open.../riv/klicoveSlovo	domestic swine skin decontamination efficacy model protection chemical warfare agents reactivators vivo in-vitro organophosphorus compounds
http://linked.open...odStatuVydavatele	CR - Kostarická republika
http://linked.open...ontrolniKodProRIV	[4D213A015817]
http://linked.open...i/riv/nazevZdroje	Arhiv za Higijenu Rada i Toksikologiju
http://linked.open...in/vavai/riv/obor	KA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	64
http://linked.open...iv/tvurceVysledku	Cabal, Jiří Kuča, Kamil Misík, Jan Pavlíková, Růžena
http://linked.open...ain/vavai/riv/wos	000321168600003
issn	0004-1254
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.2478/10004-1254-64-2013-2290

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