About: Resorcylic acid lactones as protein kinase inhibitors and naturally occurring toxins

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Resorcylic acid lactones as protein kinase inhibitors and naturally occurring toxins Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Resorcylic acid lactones (RALs) are polyketide natural products with a large macrocyclic ring fused to a resorcylic acid residue. Some RALs contain an,-unsaturated ketone in the macrocycle. So far 46 kinases have been identified that could be potentially targeted by this family of compounds. RALs are of interest for their modulation of growth, and tentatively for the treatment of cancer and neurodegenerative diseases. RALs containing a cis-enone are susceptible to Michael addition reactions with the cysteine residue in the kinase nucleotide binding site, and thus serve as potent inhibitors of several protein kinases-they therefore represent a unique pharmacophore. Notably, this moiety has been shown to be effective also in vivo. This mini-review focuses on the structure and biological effects of the most important RALs, namely zearalenone, hypothemycin, pochonins, lasiodiplodins, aigialomycins, cochlicomycins, zaenols, and paecilomycins. Finally, the review also deals with radicicol, which is a nanomolar inhibitor of the chaperone Hsp90, whose suppression leads to a combinatorial block of cancer-causing pathways. Resorcylic acid lactones (RALs) are polyketide natural products with a large macrocyclic ring fused to a resorcylic acid residue. Some RALs contain an,-unsaturated ketone in the macrocycle. So far 46 kinases have been identified that could be potentially targeted by this family of compounds. RALs are of interest for their modulation of growth, and tentatively for the treatment of cancer and neurodegenerative diseases. RALs containing a cis-enone are susceptible to Michael addition reactions with the cysteine residue in the kinase nucleotide binding site, and thus serve as potent inhibitors of several protein kinases-they therefore represent a unique pharmacophore. Notably, this moiety has been shown to be effective also in vivo. This mini-review focuses on the structure and biological effects of the most important RALs, namely zearalenone, hypothemycin, pochonins, lasiodiplodins, aigialomycins, cochlicomycins, zaenols, and paecilomycins. Finally, the review also deals with radicicol, which is a nanomolar inhibitor of the chaperone Hsp90, whose suppression leads to a combinatorial block of cancer-causing pathways. (en)
Title	Resorcylic acid lactones as protein kinase inhibitors and naturally occurring toxins Resorcylic acid lactones as protein kinase inhibitors and naturally occurring toxins (en)
skos:prefLabel	Resorcylic acid lactones as protein kinase inhibitors and naturally occurring toxins Resorcylic acid lactones as protein kinase inhibitors and naturally occurring toxins (en)
skos:notation	RIV/00179906:_____/13:10143953!RIV14-MZ0-00179906
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.30.0012)
http://linked.open...iv/cisloPeriodika	13
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Soukup, Ondřej Kuča, Kamil Patočka, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	102622
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/13:10143953
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	zearalenone; resorcylic acid lactones; radicicol; protein kinase inhibitors; pochonins; mycotoxins; Hypothemycin (en)
http://linked.open.../riv/klicoveSlovo	zearalenone Hypothemycin pochonins radicicol resorcylic acid lactones mycotoxins protein kinase inhibitors
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[9236DDBC270F]
http://linked.open...i/riv/nazevZdroje	Mini reviews in medicinal chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Postgraduants of FN HK
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Kuča, Kamil Patočka, Jiří Soukup, Ondřej
http://linked.open...ain/vavai/riv/wos	000325755800004
issn	1389-5575
number of pages	6 (xsd:int)

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software