About: Hepatic Arterial Infusion of Irinotecan, 5-Fluorouracil and Leucovorin in Patients with Liver Metastases from Colorectal Carcinoma

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About: Hepatic Arterial Infusion of Irinotecan, 5-Fluorouracil and Leucovorin in Patients with Liver Metastases from Colorectal Carcinoma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aim: The aim of the present study was to evaluate single center experience with hepatic arterial infusion (HA!) of irinotecan, 5-fluorouracil and leucovorin in patients with liver metastases from colorectal carcinoma (CRC). Patients and Methods: A retrospective analysis of 68 patients treated between 1998 and 2007 was performed. Results: Among 60 patients who had no simultaneous liver-directed procedure (LDP), the best results obtained were complete response in two patients (3%), partial response in 18 patients (30%), and stable disease in 23 patients (38%), for an overall disease control rate of 72%. Median progression-free survival was 11 months, and median survival was 24 months. Overall survival was significantly better in patients with simultaneous LDP or secondary resection. Steatosis was present in all secondary resection specimens. Conclusion: Our data demonstrate the efficacy of HAI of irinotecan combined with 5-fluorouracil and leucovorin for liver metastases from CRC, specifically in patients also treated with LDP. Aim: The aim of the present study was to evaluate single center experience with hepatic arterial infusion (HA!) of irinotecan, 5-fluorouracil and leucovorin in patients with liver metastases from colorectal carcinoma (CRC). Patients and Methods: A retrospective analysis of 68 patients treated between 1998 and 2007 was performed. Results: Among 60 patients who had no simultaneous liver-directed procedure (LDP), the best results obtained were complete response in two patients (3%), partial response in 18 patients (30%), and stable disease in 23 patients (38%), for an overall disease control rate of 72%. Median progression-free survival was 11 months, and median survival was 24 months. Overall survival was significantly better in patients with simultaneous LDP or secondary resection. Steatosis was present in all secondary resection specimens. Conclusion: Our data demonstrate the efficacy of HAI of irinotecan combined with 5-fluorouracil and leucovorin for liver metastases from CRC, specifically in patients also treated with LDP. (en)
Title	Hepatic Arterial Infusion of Irinotecan, 5-Fluorouracil and Leucovorin in Patients with Liver Metastases from Colorectal Carcinoma Hepatic Arterial Infusion of Irinotecan, 5-Fluorouracil and Leucovorin in Patients with Liver Metastases from Colorectal Carcinoma (en)
skos:prefLabel	Hepatic Arterial Infusion of Irinotecan, 5-Fluorouracil and Leucovorin in Patients with Liver Metastases from Colorectal Carcinoma Hepatic Arterial Infusion of Irinotecan, 5-Fluorouracil and Leucovorin in Patients with Liver Metastases from Colorectal Carcinoma (en)
skos:notation	RIV/00179906:_____/12:10133722!RIV13-MZ0-00179906
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NS9690)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Nová, Markéta Malířová, Eva Ryška, Aleš Dvořák, Josef Krajina, Antonín Melichar, Bohuslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	138815
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/12:10133722
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	irinotecan; hepatic arterial infusion; colorectal carcinoma; 5-Fluorouracil (en)
http://linked.open.../riv/klicoveSlovo	5-Fluorouracil hepatic arterial infusion irinotecan colorectal carcinoma
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[B6673849975A]
http://linked.open...i/riv/nazevZdroje	Anticancer Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Preoperative Regional Chemotherapy in Colon Cancer Patients
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Dvořák, Josef Krajina, Antonín Melichar, Bohuslav Nová, Markéta Ryška, Aleš Malířová, Eva Vobořil, Zbyněk Weiner, Pavel
http://linked.open...ain/vavai/riv/wos	000312040000047
issn	0250-7005
number of pages	7 (xsd:int)

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