About: Gyromitrin, mushroom toxin of Gyromitra Spp.

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.vojenskaskola.cz/school/ud/fmhs/research_development/Documents/MMSL_2012_2_3_WWW.pdf
Description	Gyromitra esculenta (Persoon ex Fries) mushrooms have been responsible for severe intoxications and even deaths. Clinical data are characterized primarily by vomiting and diarrhea and after a while by jaundice, convulsions and coma. Other Gyromitra species which may be of concern are G. fastigiata and G. gigas; nevertheless, recent advances in chromatography, biochemistry and toxicology have established that other species within the Ascomycetes may also prove toxic. Their toxins, mainly gyromitrin (N-methyl-N-formyl- N-acetyl-hydrazone) and their higher homologues are converted in the milieu of human stomach into N-methyl-N-formylhydrazine (MFH), then into N-methylhydrazine (MH). The toxicity of these latter chemicals, which are mainly hepatotoxic and even carcinogenic, has been established through in vivo and in vitro experiments with cell cultures and biochemical systems. Considering the chemical structure and the reactivity of these natural compounds, chemical and biochemical mechanisms are defined in order to explain their intrinsic biological activity. These findings imply that consumption of G. esculenta could present a carcinogenic as well as an acutely toxic health hazard. Gyromitra esculenta (Persoon ex Fries) mushrooms have been responsible for severe intoxications and even deaths. Clinical data are characterized primarily by vomiting and diarrhea and after a while by jaundice, convulsions and coma. Other Gyromitra species which may be of concern are G. fastigiata and G. gigas; nevertheless, recent advances in chromatography, biochemistry and toxicology have established that other species within the Ascomycetes may also prove toxic. Their toxins, mainly gyromitrin (N-methyl-N-formyl- N-acetyl-hydrazone) and their higher homologues are converted in the milieu of human stomach into N-methyl-N-formylhydrazine (MFH), then into N-methylhydrazine (MH). The toxicity of these latter chemicals, which are mainly hepatotoxic and even carcinogenic, has been established through in vivo and in vitro experiments with cell cultures and biochemical systems. Considering the chemical structure and the reactivity of these natural compounds, chemical and biochemical mechanisms are defined in order to explain their intrinsic biological activity. These findings imply that consumption of G. esculenta could present a carcinogenic as well as an acutely toxic health hazard. (en)
Title	Gyromitrin, mushroom toxin of Gyromitra Spp. Gyromitrin, mushroom toxin of Gyromitra Spp. (en)
skos:prefLabel	Gyromitrin, mushroom toxin of Gyromitra Spp. Gyromitrin, mushroom toxin of Gyromitra Spp. (en)
skos:notation	RIV/00179906:_____/12:10128171!RIV13-MZ0-00179906
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kuča, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	138560
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/12:10128171
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N-methyl-N-formyl-hydrazine; N-methyl-N-formyl-N-acetyl-hydrazone; gyromitrin; mycotoxin; Gyromitra esculenta (en)
http://linked.open.../riv/klicoveSlovo	Gyromitra esculenta N-methyl-N-formyl-N-acetyl-hydrazone N-methyl-N-formyl-hydrazine gyromitrin mycotoxin
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[7E59585CDA3A]
http://linked.open...i/riv/nazevZdroje	Vojenské zdravotnické listy
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	81
http://linked.open...iv/tvurceVysledku	Kuča, Kamil Patočka, Jiří Pita, Rene
issn	0372-7025
number of pages	7 (xsd:int)

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