About: The Role of Autoimmunity in Gastroenterology

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1159/000336685
Description	Crohn's disease (CD) is an immune-mediated chronic intestinal disorder thought to be the result of an aggressive immune response to a subset of enteric bacteria in a genetically predisposed host. Numerous environmental factors are apparently involved in disease pathogenesis. Impaired ability of CD patients to control the gut microflora is associated with defects in the production of some antibacterial compounds (cryptdins) by epithelial cells. In addition, there are the defects in cytoplasmic NOD-like receptors which are sensing intracellularly localized bacteria in CD patients. These defects together with the failure to induce autophagy lead to lack of bacterial clearance and subsequently to mucosal immunopathology. Crohn's disease (CD) is an immune-mediated chronic intestinal disorder thought to be the result of an aggressive immune response to a subset of enteric bacteria in a genetically predisposed host. Numerous environmental factors are apparently involved in disease pathogenesis. Impaired ability of CD patients to control the gut microflora is associated with defects in the production of some antibacterial compounds (cryptdins) by epithelial cells. In addition, there are the defects in cytoplasmic NOD-like receptors which are sensing intracellularly localized bacteria in CD patients. These defects together with the failure to induce autophagy lead to lack of bacterial clearance and subsequently to mucosal immunopathology. (en)
Title	The Role of Autoimmunity in Gastroenterology The Role of Autoimmunity in Gastroenterology (en)
skos:prefLabel	The Role of Autoimmunity in Gastroenterology The Role of Autoimmunity in Gastroenterology (en)
skos:notation	RIV/00179906:_____/12:10123672!RIV13-MZ0-00179906
http://linked.open...avai/riv/aktivita	I S Z
http://linked.open...avai/riv/aktivity	I, S, Z(MSM0021620812)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Krejsek, Jan Andrýs, Ctirad Kondělková, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	165968
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/12:10123672
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Inflammation; Autophagy; NOD-like receptors; Pattern recognition receptors; Innate immunity; Genetics; Crohn's disease (en)
http://linked.open.../riv/klicoveSlovo	Innate immunity Genetics Autophagy Inflammation Crohn's disease NOD-like receptors Pattern recognition receptors
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[E74A6A0172CB]
http://linked.open...i/riv/nazevZdroje	Digestive Diseases
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Andrýs, Ctirad Krejsek, Jan Hrnčířová, Lucia Kondělková, Kateřina
http://linked.open...ain/vavai/riv/wos	000305679900014
http://linked.open...n/vavai/riv/zamer	Chronická onemocnění vznikající na podkladě nepřiměřené reaktivity imunitního systému, jejich patogeneze a možnosti včasné diagnostiky a léčby
issn	0257-2753
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1159/000336685

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