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rdf:type
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Description
| - CD200/CD200R are highly conserved type I paired membrane glycoproteins that belong to Ig superfamily, containing two immunoglobulin-like domain (V, C). CD200 is broadly distributed on a variety of cell types, whereas CD200R is primarily expressed on myeloid and lymphoid cells. They fulfill multiple functions in tuning of inflammation. The interaction between CD200/CD200R results in activation of the intracellular inhibitory pathway with RasGAP recruitment and thus contributes to effector cells inhibition. It was confirmed that the CD200R activation stimulates differentiation of T cells to the Treg subset, upregulates indoleamine 2,3-dioxygenase activity, modulates cytokine environment from Th1 to Th2 pattern, potentiate an antiinflammatory IL-10 and TGF-β synthesis. CD200/CD200R are required for maintaining self-tolerance. Many studies demonstrated the importance of CD200 in controlling autoimmunity, inflammation, development and spread of cancer, hypersensitivity, and spontaneous fetal loss.
- CD200/CD200R are highly conserved type I paired membrane glycoproteins that belong to Ig superfamily, containing two immunoglobulin-like domain (V, C). CD200 is broadly distributed on a variety of cell types, whereas CD200R is primarily expressed on myeloid and lymphoid cells. They fulfill multiple functions in tuning of inflammation. The interaction between CD200/CD200R results in activation of the intracellular inhibitory pathway with RasGAP recruitment and thus contributes to effector cells inhibition. It was confirmed that the CD200R activation stimulates differentiation of T cells to the Treg subset, upregulates indoleamine 2,3-dioxygenase activity, modulates cytokine environment from Th1 to Th2 pattern, potentiate an antiinflammatory IL-10 and TGF-β synthesis. CD200/CD200R are required for maintaining self-tolerance. Many studies demonstrated the importance of CD200 in controlling autoimmunity, inflammation, development and spread of cancer, hypersensitivity, and spontaneous fetal loss. (en)
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Title
| - CD200-CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; part I: CD200/CD200R structure, activation, and function
- CD200-CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; part I: CD200/CD200R structure, activation, and function (en)
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skos:prefLabel
| - CD200-CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; part I: CD200/CD200R structure, activation, and function
- CD200-CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; part I: CD200/CD200R structure, activation, and function (en)
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skos:notation
| - RIV/00179906:_____/12:10123623!RIV13-MZ0-00179906
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00179906:_____/12:10123623
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - IDO; inflammation; inhibition mechanisms; CD200R; CD200 (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Kralove
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Andrýs, Ctirad
- Krejsek, Jan
- Koláčková, Martina
- Kuneš, Pavel
- Holmannová, Drahomíra
- Kondělková, Kateřina
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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