About: The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers

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About: The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://86.120.250.122:8082/2011/numarul1/fulltext/The%20Effect%20of%20Oral%20Sodium%20Loading%20and%20Saline%20Infusion%20on%20Direct%20Active%20Renin%20in%20Healthy%20Volunteers.pdf
Description	In patients with suspected primary aldosteronism (PA), the aldosteroneto-renin ratio (ARR) is the most frequently recommended screening test. Further evaluation is based on hormonal changes during volume expansion. Both analyses are critically dependent on an accurate estimation of renin concentration. Direct active renin (DAR) is a novel laboratory technique used for plasma renin assessment. The objective of this study was to evaluate DAR for use in PA diagnostic work-ups. The study enrolled 69 healthy volunteers. Blood sampling was conducted before and after an increase in oral salt intake. Furthermore, a subset of 32 individuals uderwent a saline infusion suppression terst. DAR and serum aldosterone were measured in all blood samples. To calculate the ARR, serum aldosterone and DAR were expressed in ng/L. ARR values (median (range); 97,5 percentile) associated with normal and elevated oral salt intake were 8.4 (0.6-37.7); 26.3, and 6.8 (1.1-37.7); 19.6, respectively. DAR and serum aldosterone concentrations (median (range); 97.5 percentile) after saline infusion suppression were 2.9 (2.7-10.7); 7.2 ng/L and 30 (30-72); 54 pmol/L, respectively. The observed values may be useful in excluding a diagnosis of PA. In patients with suspected primary aldosteronism (PA), the aldosteroneto-renin ratio (ARR) is the most frequently recommended screening test. Further evaluation is based on hormonal changes during volume expansion. Both analyses are critically dependent on an accurate estimation of renin concentration. Direct active renin (DAR) is a novel laboratory technique used for plasma renin assessment. The objective of this study was to evaluate DAR for use in PA diagnostic work-ups. The study enrolled 69 healthy volunteers. Blood sampling was conducted before and after an increase in oral salt intake. Furthermore, a subset of 32 individuals uderwent a saline infusion suppression terst. DAR and serum aldosterone were measured in all blood samples. To calculate the ARR, serum aldosterone and DAR were expressed in ng/L. ARR values (median (range); 97,5 percentile) associated with normal and elevated oral salt intake were 8.4 (0.6-37.7); 26.3, and 6.8 (1.1-37.7); 19.6, respectively. DAR and serum aldosterone concentrations (median (range); 97.5 percentile) after saline infusion suppression were 2.9 (2.7-10.7); 7.2 ng/L and 30 (30-72); 54 pmol/L, respectively. The observed values may be useful in excluding a diagnosis of PA. (en)
Title	The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers (en)
skos:prefLabel	The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers (en)
skos:notation	RIV/00179906:_____/11:10108580!RIV12-MZ0-00179906
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620817), Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Pelouch, Radek Malířová, Eva Solař, Miroslav Ceral, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	196384
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/11:10108580
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	direct active renin; primary aldosteronism (en)
http://linked.open.../riv/klicoveSlovo	primary aldosteronism direct active renin
http://linked.open...odStatuVydavatele	RO - Rumunsko
http://linked.open...ontrolniKodProRIV	[AB1E1403BC86]
http://linked.open...i/riv/nazevZdroje	Acta Endocrinology
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Ceral, Jiří Solař, Miroslav Pelouch, Radek Kopecká, P. Malířová, Eva
http://linked.open...ain/vavai/riv/wos	000289007600004
http://linked.open...n/vavai/riv/zamer	Invasive Approaches to Rescue and Regenerate Jeopardized Myocardium Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	1841-0987
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.4183/aeb.2011.33

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