About: Genotyping of varicella-zoster virus (VZV) wild-type strains isolated in the Czech Republic

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About: Genotyping of varicella-zoster virus (VZV) wild-type strains isolated in the Czech Republic Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://biomed.papers.upol.cz/pdfs/bio/2011/04/11.pdf
Description	A total of 273 clinical samples were obtained from patients exhibiting symptoms of varicella zoster virus (VZV) infection manifested as chickenpox or herpes zoster (HZ) treated in the Faculty Hospital of Charles University, Medical School in Hradec Kralove, Czech Republic Characterization of individual VZV strains was performed utilizing restriction fragment length polymorphisms (RFLPs), PCR and sequencing. Single nucleotide polymorphisms (SNP) in the open reading frames (ORF) 21, 22 and 50 were used to identify individual VZV strains. All clinical isolates (97 from varicella, 176 from herpes zoster) were VZV positive wild-type strains. Sequencing analysis showed that 89 isolates were of the European E1 genotype, 180 were of the European E2 genotype and 2 were identified as the Mosaic M1 strain. In addition, two unusual genotypes were identified, both representing a combination of E1 and M2 strain specific SNPs. Our prospective VZV genotyping study is the first one monitoring the situation in Czech Republic using such a large set of clinical specimens A total of 273 clinical samples were obtained from patients exhibiting symptoms of varicella zoster virus (VZV) infection manifested as chickenpox or herpes zoster (HZ) treated in the Faculty Hospital of Charles University, Medical School in Hradec Kralove, Czech Republic Characterization of individual VZV strains was performed utilizing restriction fragment length polymorphisms (RFLPs), PCR and sequencing. Single nucleotide polymorphisms (SNP) in the open reading frames (ORF) 21, 22 and 50 were used to identify individual VZV strains. All clinical isolates (97 from varicella, 176 from herpes zoster) were VZV positive wild-type strains. Sequencing analysis showed that 89 isolates were of the European E1 genotype, 180 were of the European E2 genotype and 2 were identified as the Mosaic M1 strain. In addition, two unusual genotypes were identified, both representing a combination of E1 and M2 strain specific SNPs. Our prospective VZV genotyping study is the first one monitoring the situation in Czech Republic using such a large set of clinical specimens (en)
Title	Genotyping of varicella-zoster virus (VZV) wild-type strains isolated in the Czech Republic Genotyping of varicella-zoster virus (VZV) wild-type strains isolated in the Czech Republic (en)
skos:prefLabel	Genotyping of varicella-zoster virus (VZV) wild-type strains isolated in the Czech Republic Genotyping of varicella-zoster virus (VZV) wild-type strains isolated in the Czech Republic (en)
skos:notation	RIV/00179906:_____/11:10107427!RIV12-MZ0-00179906
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP304/10/1161)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Salavec, Miloslav Kosina, Pavel Prášil, Petr Plíšek, Stanislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	201051
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/11:10107427
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	single nucleotide polymorphism; Czech Republic; genotyping; open reading frame; Wild-type; Varicella-zoster virus (en)
http://linked.open.../riv/klicoveSlovo	single nucleotide polymorphism Wild-type open reading frame Czech Republic Varicella-zoster virus genotyping
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[8D99F103DFF9]
http://linked.open...i/riv/nazevZdroje	Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, CzechoSK
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Role of virus-associated host-derived proteins in virus induced T cell dysfunction
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	155
http://linked.open...iv/tvurceVysledku	Boštík, Pavel Boštíková, Vanda Chlíbek, Roman Kosina, Pavel Plíšek, Stanislav Prášil, Petr Salavec, Miloslav Smetana, Jan Špliňo, Miroslav
http://linked.open...ain/vavai/riv/wos	000299697000012
issn	1213-8118
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.5507/bp.2011.056

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