About: Molecular predictive factors of outcome of radiotherapy in cervical cancer

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Radical radiotherapy with concurrent cisplatin-based chemotherapy is an established treatment for cervical cancer patients with stage FIGO IIB and higher. The tumor control can be achieved in 40-80% of patients, the treatment is associated with the risk of late postiradiation complications in 10-15% of cases. Detection of the factors predictive for tumor control and late morbidity is a possible direction how to individualize radiotherapy dose and technique. The aim of our review is to summarize results of studies inquiring various molecular markers predicting tumor response to radiotherapy and a risk of late complications. Radical radiotherapy with concurrent cisplatin-based chemotherapy is an established treatment for cervical cancer patients with stage FIGO IIB and higher. The tumor control can be achieved in 40-80% of patients, the treatment is associated with the risk of late postiradiation complications in 10-15% of cases. Detection of the factors predictive for tumor control and late morbidity is a possible direction how to individualize radiotherapy dose and technique. The aim of our review is to summarize results of studies inquiring various molecular markers predicting tumor response to radiotherapy and a risk of late complications. (en)
Title	Molecular predictive factors of outcome of radiotherapy in cervical cancer Molecular predictive factors of outcome of radiotherapy in cervical cancer (en)
skos:prefLabel	Molecular predictive factors of outcome of radiotherapy in cervical cancer Molecular predictive factors of outcome of radiotherapy in cervical cancer (en)
skos:notation	RIV/00179906:_____/11:10106307!RIV12-MZ0-00179906
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NT11334)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Beránek, Martin Paulíková, Simona Sirák, Igor Vošmik, Milan Drastíková, Monika Petera, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	213510
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/11:10106307
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	survivin; HPV; COX-2; Bc1-2; Ki-67; HER-2; EGFR; molecular predictive factors; radiotherapy; cervical cancer (en)
http://linked.open.../riv/klicoveSlovo	COX-2 EGFR cervical cancer Bc1-2 Ki-67 molecular predictive factors survivin HER-2 radiotherapy HPV
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[519BAC2DDAC7]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic prediction of late toxicity of radiotherapy for cervical cancer
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Beránek, Martin Drastíková, Monika Paulíková, Simona Petera, Jiří Sirák, Igor Vošmik, Milan Soumarová, Renata
http://linked.open...ain/vavai/riv/wos	000295392600002
issn	0028-2685
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.4149/neo_2011_06_469

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