About: Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma

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About: Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aims of our study were: (i) to find and validate a method for fast and reliable analysis of the D1853N (5557G}A) genetic polymorphism in the ATM (ataxia-telangiectasia mutated) gene; ii) to target mutagenesis to ATM exon 39 to receive control samples containing the 5557A allele in homozygous state; and (iii) to analyse a group of patients suffering from cervical carcinoma with adverse responses to radiotherapy. The 5557A variant was found in three of twenty women (16 %). Our data show that the prevalence of the 5557A allelic variant in cervical cancer subjects with adverse responses after irradiation does not differ from the prevalence common in Caucasians. The aims of our study were: (i) to find and validate a method for fast and reliable analysis of the D1853N (5557G}A) genetic polymorphism in the ATM (ataxia-telangiectasia mutated) gene; ii) to target mutagenesis to ATM exon 39 to receive control samples containing the 5557A allele in homozygous state; and (iii) to analyse a group of patients suffering from cervical carcinoma with adverse responses to radiotherapy. The 5557A variant was found in three of twenty women (16 %). Our data show that the prevalence of the 5557A allelic variant in cervical cancer subjects with adverse responses after irradiation does not differ from the prevalence common in Caucasians. (en)
Title	Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma (en)
skos:prefLabel	Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma (en)
skos:notation	RIV/00179906:_____/11:10105261!RIV12-MZ0-00179906
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(NT11334), Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Beránek, Martin Paulíková, Simona Sirák, Igor Vošmik, Milan Drastíková, Monika Petera, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	185645
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/11:10105261
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RFLP; PCR; DNA; treatment; diagnostics; oncology; genotyping; mutation; ATM (en)
http://linked.open.../riv/klicoveSlovo	DNA PCR diagnostics treatment ATM RFLP genotyping mutation oncology
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[D8878816AFD9]
http://linked.open...i/riv/nazevZdroje	Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Kralove
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic prediction of late toxicity of radiotherapy for cervical cancer
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Beránek, Martin Drastíková, Monika Paulíková, Simona Petera, Jiří Sirák, Igor Vošmik, Milan
http://linked.open...n/vavai/riv/zamer	Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	1211-4286
number of pages	5 (xsd:int)

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