About: Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone

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About: Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.eje-online.org/content/164/3/325.full.pdf+html
Description	The authors evaluate the efficacy and safety of coadministered lanreotide Autogel (LA: 120 mg/month) and pegvisomant (40-120 mg/week) in acromegaly. In patients partially controlled by SSAs, LA (120 mg/months) plus pegvisomant normalized IGF1 in 57,9% of patients after 7 months, at a median effective pegvisomant dose of 60 mg/week, and 78,9% at any time. In these patients, results suggest a pegvisomant-sparing effect versus daily pegvisomant monotherapy. The authors evaluate the efficacy and safety of coadministered lanreotide Autogel (LA: 120 mg/month) and pegvisomant (40-120 mg/week) in acromegaly. In patients partially controlled by SSAs, LA (120 mg/months) plus pegvisomant normalized IGF1 in 57,9% of patients after 7 months, at a median effective pegvisomant dose of 60 mg/week, and 78,9% at any time. In these patients, results suggest a pegvisomant-sparing effect versus daily pegvisomant monotherapy. (en)
Title	Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone (en)
skos:prefLabel	Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone (en)
skos:notation	RIV/00179906:_____/11:10105257!RIV12-MZ0-00179906
http://linked.open...avai/riv/aktivita	N V
http://linked.open...avai/riv/aktivity	N, V
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Čáp, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	190755
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/11:10105257
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	somatostatin analogs; acromegaly; IGF1 levels; pegvisomant; lanreotide Autogel (en)
http://linked.open.../riv/klicoveSlovo	IGF1 levels acromegaly lanreotide Autogel pegvisomant somatostatin analogs
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B83A1FDE25A1]
http://linked.open...i/riv/nazevZdroje	European Journal of Endocrinology
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	164
http://linked.open...iv/tvurceVysledku	Bernabeu, Ignacio Birman, Pascal Caron, Philippe Colao, Annamaria Marek, Josef Neggers, Sebastian Van der Lely, Aart-Jan Čáp, Jan
http://linked.open...ain/vavai/riv/wos	000287969100002
issn	0804-4643
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1530/EJE-10-0867

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