About: The endocannabinoid system in sepsis - a potential target to improve microcirculation?

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.signavitae.com/attachments/SIGNA%20VITAE%202011%206%281%29%207%20-%2013.pdf
Description	During the last decade, research has identified the endocannabinoid system (ECS) as a key regulator of essential physiological functions, including the regulation of micro vascular and immune function. Indeed, increasing evidence now suggests that release of endocannabinoids and activation of cannabinoid receptors occurs during sepsis and that manipulation of the ECS may represent an important therapeutic target to improve microcirculation in sepsis. In this review, the pharmacology and physiology of the ECS and the involvement of cannabinoids, cannabinoid receptors and non-CB1R/CB2R pathways related to ECS activation will be described. This information will increase our comprehension of the role of lipid signaling pathways in sepsis and may lead to the identification of new drug targets for the treatment of impaired microcirculation. During the last decade, research has identified the endocannabinoid system (ECS) as a key regulator of essential physiological functions, including the regulation of micro vascular and immune function. Indeed, increasing evidence now suggests that release of endocannabinoids and activation of cannabinoid receptors occurs during sepsis and that manipulation of the ECS may represent an important therapeutic target to improve microcirculation in sepsis. In this review, the pharmacology and physiology of the ECS and the involvement of cannabinoids, cannabinoid receptors and non-CB1R/CB2R pathways related to ECS activation will be described. This information will increase our comprehension of the role of lipid signaling pathways in sepsis and may lead to the identification of new drug targets for the treatment of impaired microcirculation. (en)
Title	The endocannabinoid system in sepsis - a potential target to improve microcirculation? The endocannabinoid system in sepsis - a potential target to improve microcirculation? (en)
skos:prefLabel	The endocannabinoid system in sepsis - a potential target to improve microcirculation? The endocannabinoid system in sepsis - a potential target to improve microcirculation? (en)
skos:notation	RIV/00179906:_____/11:10103759!RIV12-MZ0-00179906
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Černý, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	197452
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/11:10103759
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cannabinoid receptors; cannabinoids; lipid mediators; microcirculation; sepsis; systemic inflammation (en)
http://linked.open.../riv/klicoveSlovo	cannabinoid receptors lipid mediators microcirculation systemic inflammation sepsis cannabinoids
http://linked.open...odStatuVydavatele	HR - Chorvatská republika
http://linked.open...ontrolniKodProRIV	[E3622C1D723F]
http://linked.open...i/riv/nazevZdroje	Signa Vitae
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Černý, Vladimír Kelly, Melanie Kianian, Mandana Lehmann, Christian Zhou, Juan
http://linked.open...ain/vavai/riv/wos	000293146700001
issn	1334-5605
number of pages	7 (xsd:int)

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