About: Endoglin as a possible marker of atorvastatin treatment benefit in atherosclerosis

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About: Endoglin as a possible marker of atorvastatin treatment benefit in atherosclerosis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S1043661811000727
Description	In this study, we hypothesized whether atorvastatin treatment affects endoglin/ALK-1/p-Smad1/VEGF expression in the aorta and endoglin levels in serum in ApoE/LDLR double knockout mice. In conclusion, it has been demonstrated that atorvastatin increases endoglin/ALK-1/p-Smad1/VEGF expression in aorta and decreases the size of atherosclerotic lesions, suggesting that activation of this endothelial-protective pathway might support the antiatherogenic effects of atorvastatin. Moreover, atorvastatin concurrently decreased serum levels of endoglin suggesting that monitoring of endoglin levels in blood might represent an important marker of the progression and/or treatment of atherosclerosis. In this study, we hypothesized whether atorvastatin treatment affects endoglin/ALK-1/p-Smad1/VEGF expression in the aorta and endoglin levels in serum in ApoE/LDLR double knockout mice. In conclusion, it has been demonstrated that atorvastatin increases endoglin/ALK-1/p-Smad1/VEGF expression in aorta and decreases the size of atherosclerotic lesions, suggesting that activation of this endothelial-protective pathway might support the antiatherogenic effects of atorvastatin. Moreover, atorvastatin concurrently decreased serum levels of endoglin suggesting that monitoring of endoglin levels in blood might represent an important marker of the progression and/or treatment of atherosclerosis. (en)
Title	Endoglin as a possible marker of atorvastatin treatment benefit in atherosclerosis Endoglin as a possible marker of atorvastatin treatment benefit in atherosclerosis (en)
skos:prefLabel	Endoglin as a possible marker of atorvastatin treatment benefit in atherosclerosis Endoglin as a possible marker of atorvastatin treatment benefit in atherosclerosis (en)
skos:notation	RIV/00179906:_____/11:10100653!RIV12-MZ0-00179906
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM0021620820), Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Andrýs, Ctirad
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	197459
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/11:10100653
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	atherosclerosis; atorvastatin; VEGF; p-Smad1; ALK-1; endoglin (en)
http://linked.open.../riv/klicoveSlovo	ALK-1 atorvastatin endoglin p-Smad1 atherosclerosis VEGF
http://linked.open...odStatuVydavatele	IT - Italská republika
http://linked.open...ontrolniKodProRIV	[209D9A92A4D6]
http://linked.open...i/riv/nazevZdroje	Pharmacological Research
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	64
http://linked.open...iv/tvurceVysledku	Andrýs, Ctirad Brčáková, Eva Mičuda, Stanislav Nachtigal, Petr Rathouská, Jana Slanařová, Martina Stráský, Zbyněk Večeřová, Lenka Müllerová, Zuzana
http://linked.open...ain/vavai/riv/wos	000291907900008
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	1043-6618
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.phrs.2011.03.008

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