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Description
  • In a series of 1,177 patients with surgical valve resection, there were 128 (10.9 %) patients with the histological finding of bone and/or cartilage formation (bony metaplasia; heterotopic ossification) in the excised valve (119 aortic, 9 mitral). The incidence was higher in men (12.8%) than in women (8.5%). The bony metaplasia was always associated with valvular calcification. The metaplastic changes were encountered in all types of calcific aortic valve disease (senile, bicuspid valve, post-rheumatic). The marrow of the heterotopic lamellar bone was mostly composed of adipose tissue. Frequently, it showed chronic inflammation with polyclonal plasmocytic infiltration. Complete haematopoiesis was present only rarely.
  • In a series of 1,177 patients with surgical valve resection, there were 128 (10.9 %) patients with the histological finding of bone and/or cartilage formation (bony metaplasia; heterotopic ossification) in the excised valve (119 aortic, 9 mitral). The incidence was higher in men (12.8%) than in women (8.5%). The bony metaplasia was always associated with valvular calcification. The metaplastic changes were encountered in all types of calcific aortic valve disease (senile, bicuspid valve, post-rheumatic). The marrow of the heterotopic lamellar bone was mostly composed of adipose tissue. Frequently, it showed chronic inflammation with polyclonal plasmocytic infiltration. Complete haematopoiesis was present only rarely. (en)
  • V sestavě 1.177 pacientů s resekcí srdeční chlopně bylo 128 (10,9 %) pacientů s histologickým nálezem tvorby kosti a/nebo chrupavky (kostní metaplasie; heterotopická osifikace) v excidované chlopni (119 aortálních, 9 mitrálních). Četnost byla vyšší u mužů (12,8 %) než u žen (8,5 %). Kostní metaplazie byla ždy spojena s kalcifikací chlopně. Metaplastické změny byly zastiženy ve všech typech kalcifikované aortální stenózy (senilní, dvojcípá chlopeň, porevmatická). Dřeň heterotopní trámčité kosti byla většinou tvořena tukovou tkání. Často v ní byl chronický zánět s infiltrátem z polyklonálních plazmatických buněk. Výjimečně byla přítomná úplná hemopoéza. (cs)
Title
  • Bone formation in cardiac valves: a histopathological study of 128 cases
  • Bone formation in cardiac valves: a histopathological study of 128 cases (en)
  • Tvorba kosti v srdečních chlopních: histopatologická studie 128 případů (cs)
skos:prefLabel
  • Bone formation in cardiac valves: a histopathological study of 128 cases
  • Bone formation in cardiac valves: a histopathological study of 128 cases (en)
  • Tvorba kosti v srdečních chlopních: histopatologická studie 128 případů (cs)
skos:notation
  • RIV/00179906:_____/07:00000368!RIV08-MZ0-00179906
http://linked.open.../vavai/riv/strany
  • 653;657
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 412130
http://linked.open...ai/riv/idVysledku
  • RIV/00179906:_____/07:00000368
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • bony metaplasia; cardiac valves; calcific aortic stenosis; bone marrow (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [32FAF5B084F0]
http://linked.open...i/riv/nazevZdroje
  • Virchows Archiv
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 450
http://linked.open...iv/tvurceVysledku
  • Dominik, Jan
  • Šteiner, Ivo
  • Kašparová, Petra
  • Kohout, Aleš
http://linked.open...n/vavai/riv/zamer
issn
  • 0945-6317
number of pages
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