About: Differential effects of statins and alendronate on cholinesterases in serum and brain of rats

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About: Differential effects of statins and alendronate on cholinesterases in serum and brain of rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cílem předkládané práce bylo otestovat vliv tradičních (statiny) a netradičních (bisphosphonáty) léků snižujících cholesterol na aktivitu acetyl- a butyrylcholinesterázy v krvi a na acetylcholinesterázu v mozku, s ohledem na jejich schopnost proniknout hematoencefalickou bariérou. Uzavíráme, že léky snižující cholesterol jsou schopné snížit aktivitu acetylcholinesterázyv mozku, pokud proniknou hematoencefalickou bariérou. (cs) The aim of the present study was to test classical (statins) and atypical (bisphosphonates) cholesterol-lowering drugs for possible effects on blood acetyl- and butyrylcholinesterase and brain AChE activities with respect to their blood-brain barrier permeability. We conclude that cholesterol-lowering drugs may inhibit AChE activity in brain providing they penetrate blood-brain barrier. The aim of the present study was to test classical (statins) and atypical (bisphosphonates) cholesterol-lowering drugs for possible effects on blood acetyl- and butyrylcholinesterase and brain AChE activities with respect to their blood-brain barrier permeability. We conclude that cholesterol-lowering drugs may inhibit AChE activity in brain providing they penetrate blood-brain barrier. (en)
Title	Differential effects of statins and alendronate on cholinesterases in serum and brain of rats Differential effects of statins and alendronate on cholinesterases in serum and brain of rats (en) Vliv statinů a alendronátu na cholinesterázy v séru (cs)
skos:prefLabel	Differential effects of statins and alendronate on cholinesterases in serum and brain of rats Differential effects of statins and alendronate on cholinesterases in serum and brain of rats (en) Vliv statinů a alendronátu na cholinesterázy v séru (cs)
skos:notation	RIV/00179906:_____/07:00000326!RIV08-MZ0-00179906
http://linked.open.../vavai/riv/strany	765;770
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Palička, Vladimír Cibičková, Ľubica Cibiček, Norbert
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	417282
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/07:00000326
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	simvastatin; atorvastatin; alendronate; cholesterol; acetylcholinesterase; Alzheimer´s disease (en)
http://linked.open.../riv/klicoveSlovo	atorvastatin cholesterol alendronate acetylcholinesterase simvastatin Alzheimer´s disease
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[E3020CE4DCA2]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	56
http://linked.open...iv/tvurceVysledku	Palička, Vladimír Cibiček, Norbert Cibičková, Lubica
http://linked.open...n/vavai/riv/zamer	Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	0862-8408
number of pages	6 (xsd:int)

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