About: The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: Preliminary results

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About: The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: Preliminary results Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Measurable traits of human personality may mark the predispostion to psychopathology. Increase novelty seeking plays an important role in the pathogenesis of substance abuse. Novelty seeking, one of the fundamental traits of the human temperament, is relate to dopamine. Catechol-O-methyltransferase (COMT) is essential for dopamine inactivation. The aim of our study was to assess whether the COMT gene Val158Met functional polymorphism in patients dependent on methamphetamine is related to their novelty siiking score. Measurable traits of human personality may mark the predispostion to psychopathology. Increase novelty seeking plays an important role in the pathogenesis of substance abuse. Novelty seeking, one of the fundamental traits of the human temperament, is relate to dopamine. Catechol-O-methyltransferase (COMT) is essential for dopamine inactivation. The aim of our study was to assess whether the COMT gene Val158Met functional polymorphism in patients dependent on methamphetamine is related to their novelty siiking score. (en) Některé měřitelné rysy lidské osobnosti predisponují k rozvoji určité psychopatologie. Zvýšená potřeba vyhledávat nové podněty (novelty seeking, NS) hraje významnou roli v etiopatogenezi závislosti na návykových látkách. Povahový rys NS má vztah k dopaminergní neurotransmisi. Catechol-O-methyltransferáza (COMT) je nezbytná při odbourávání dopaminu. Cílem naší práce bylo zjistit, zda funkční polymorfismus Val158Met genu pro COMT má vztah ke skóru NS u osob, závislých na pervitinu. (cs)
Title	The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: Preliminary results Polymorfismus Val158Met genu pro COMT a novelty seeking u závislosti na pervitinu (cs) The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: Preliminary results (en)
skos:prefLabel	The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: Preliminary results Polymorfismus Val158Met genu pro COMT a novelty seeking u závislosti na pervitinu (cs) The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: Preliminary results (en)
skos:notation	RIV/00179906:_____/06:00000079!RIV07-MZ0-00179906
http://linked.open.../vavai/riv/strany	799;802
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Libiger, Jan Beránek, Martin Čížek, Jiří Hosák, Ladislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	469532
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/06:00000079
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	methamphetamine dependence; novelty-seeking behavior; COMT; COMT Gene Val158Met polymorphism; dopamine (en)
http://linked.open.../riv/klicoveSlovo	methamphetamine dependence COMT Gene Val158Met polymorphism novelty-seeking behavior dopamine COMT
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[7B650B5359CA]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Beránek, Martin Hosák, Ladislav Libiger, Jan Čížek, Jiří
http://linked.open...n/vavai/riv/zamer	Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	0172-780X
number of pages	4 (xsd:int)

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